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Evocalcet
Evocalcet is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against extracellular calcium-sensing receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Secondary hyperparathyroidismD006962EFO_1001173124——6
Parathyroid neoplasmsD010282——1——1
Primary hyperparathyroidismD049950EFO_0008519E21.0——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperparathyroidismD006961EFO_0008506E21.311———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEVOCALCET
INNevocalcet
Description
Evocalcet (trade name Orkedia) is a drug for the treatment of hyperparathyroidism. It acts as a calcium-sensing receptor agonist.
Classification
Small molecule
Drug classcalcium-sensing receptor (CaSR) agonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](N[C@H]1CCN(c2ccc(CC(=O)O)cc2)C1)c1cccc2ccccc12
Identifiers
PDB—
CAS-ID870964-67-3
RxCUI—
ChEMBL IDCHEMBL4297621
ChEBI ID—
PubChem CID71242808
DrugBankDB12388
UNII IDE58MLH082P (ChemIDplus, GSRS)
Target
Agency Approved
CASR
CASR
Organism
Homo sapiens
Gene name
CASR
Gene synonyms
GPRC2A, PCAR1
NCBI Gene ID
846
Protein name
extracellular calcium-sensing receptor
Protein synonyms
parathyroid Ca(2+)-sensing receptor 1, Parathyroid cell calcium-sensing receptor 1, PCaR1
Uniprot ID
Q4PJ19
Mouse ortholog
Casr (12374)
extracellular calcium-sensing receptor (Q9R1Y2)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 82 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16 adverse events reported
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