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Fenobam
Fenobam is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target metabotropic glutamate receptor 5.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperalgesiaD0069301————1
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFENOBAM
INNfenobam
Description
Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it has been used as a lead compound for the development of a range of newer mGluR5 antagonists.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1
Identifiers
PDB6FFH
CAS-ID57653-26-6
RxCUI—
ChEMBL IDCHEMBL239800
ChEBI ID—
PubChem CID162834
DrugBankDB12931
UNII ID078RCY7I27 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GRM5
GRM5
Organism
Homo sapiens
Gene name
GRM5
Gene synonyms
GPRC1E, MGLUR5
NCBI Gene ID
2915
Protein name
metabotropic glutamate receptor 5
Protein synonyms
glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86
Uniprot ID
P41594
Mouse ortholog
Grm5 (108071)
metabotropic glutamate receptor 5 (Q3UVX5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 426 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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