Fimepinostat
Fimepinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, histone deacetylase 2, polyamine deacetylase HDAC10, histone deacetylase 6, histone deacetylase 1, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, histone deacetylase 11, and histone deacetylase 3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 1 | 1 | — | — | — | 2 | |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | C85.9 | 2 | — | — | — | — | 2 | |
| Neoplasms | D009369 | C80 | 2 | — | — | — | — | 2 | |
| Glioblastoma | D005909 | EFO_0000515 | 1 | — | — | — | — | 1 | |
| Glioma | D005910 | EFO_0000520 | 1 | — | — | — | — | 1 | |
| Medulloblastoma | D008527 | 1 | — | — | — | — | 1 | ||
| Astrocytoma | D001254 | EFO_0000271 | 1 | — | — | — | — | 1 | |
| Diffuse intrinsic pontine glioma | D000080443 | 1 | — | — | — | — | 1 | ||
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Neuroblastoma | D009447 | EFO_0000621 | 1 | — | — | — | — | 1 | |
| Triple negative breast neoplasms | D064726 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FIMEPINOSTAT |
| INN | fimepinostat |
| Description | Fimepinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, histone deacetylase 2, polyamine deacetylase HDAC10, histone deacetylase 6, histone deacetylase 1, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, histone deacetylase 11, and histone deacetylase 3. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 1339928-25-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3622533 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3S9RX35S5X (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PIK3CD
PIK3CD
PIK3CG
PIK3CG
PIK3CB
PIK3CB
HDAC2
HDAC2
HDAC10
HDAC10
HDAC6
HDAC6
HDAC1
HDAC1
PIK3CA
PIK3CA
HDAC11
HDAC11
HDAC3
HDAC3
Organism
Homo sapiens
Gene name
PIK3CD
Gene synonyms
NCBI Gene ID
Protein name
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Protein synonyms
p110delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20, phosphoinositide-3-kinase C, phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta, PI3-kinase p110 subunit delta, PI3Kdelta, PtdIns-3-kinase subunit p110-delta
Uniprot ID
Mouse ortholog
Pik3cd (18707)
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Q8CJ28)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 105 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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