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Firategrast
Firategrast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target integrin alpha-4, integrin beta-1, and integrin beta-7.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Relapsing-remitting multiple sclerosisD020529EFO_000392911———2
Multiple sclerosisD009103EFO_0003885G35—2———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFIRATEGRAST
INNfirategrast
Description
Firategrast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target integrin alpha-4, integrin beta-1, and integrin beta-7.
Classification
Small molecule
Drug classantiasthmatics/antiallergics (not acting primarily as antihistamines): integrin antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOCc1cc(OC)c(-c2ccc(C[C@H](NC(=O)c3c(F)cccc3F)C(=O)O)cc2)c(OC)c1
Identifiers
PDB—
CAS-ID402567-16-2
RxCUI—
ChEMBL IDCHEMBL2104967
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDOJY3SK9H5F (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ITGA4
ITGA4
ITGB1
ITGB1
ITGB7
ITGB7
Organism
Homo sapiens
Gene name
ITGA4
Gene synonyms
CD49D
NCBI Gene ID
3676
Protein name
integrin alpha-4
Protein synonyms
269C wild type, alpha 4 subunit of VLA-4 receptor, antigen CD49D, alpha-4 subunit of VLA-4 receptor, CD49 antigen-like family member D, CD49d, Integrin alpha-IV, very late activation protein 4 receptor, alpha 4 subunit, VLA-4 subunit alpha
Uniprot ID
Q7Z4L6
Mouse ortholog
Itga4 (16401)
integrin alpha-4 (Q00651)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 59 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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