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Firsocostat
Firsocostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target acetyl-CoA carboxylase 2 and acetyl-CoA carboxylase 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.8113———4
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFIRSOCOSTAT
INNfirsocostat
Description
Firsocostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target acetyl-CoA carboxylase 2 and acetyl-CoA carboxylase 1.
Classification
Small molecule
Drug classenzyme inhibitors: acetyl CoA carboxylase (ACC) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)O)c(=O)c2c(C)c(-c3ncco3)sc21)OC1CCOCC1
Identifiers
PDB—
CAS-ID1434635-54-7
RxCUI—
ChEMBL IDCHEMBL3407547
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDXE10NJQ95M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ACACB
ACACB
ACACA
ACACA
Organism
Homo sapiens
Gene name
ACACB
Gene synonyms
ACC2, ACCB
NCBI Gene ID
32
Protein name
acetyl-CoA carboxylase 2
Protein synonyms
ACC-beta, acetyl-Coenzyme A carboxylase beta
Uniprot ID
Q6TY48
Mouse ortholog
Acacb (100705)
acetyl-CoA carboxylase 2 (Q6JIZ0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 192 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3 adverse events reported
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