Flindokalner
Flindokalner is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target potassium voltage-gated channel subfamily KQT member 4, Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1, potassium voltage-gated channel subfamily KQT member 5, and potassium voltage-gated channel subfamily KQT member 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Post-traumatic headache | D051298 | G44.3 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FLINDOKALNER |
| INN | flindokalner |
| Description | Flindokalner is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target potassium voltage-gated channel subfamily KQT member 4, Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1, potassium voltage-gated channel subfamily KQT member 5, and potassium voltage-gated channel subfamily KQT member 2. |
| Classification | Small molecule |
| Drug class | opener of large conductance calcium-activated (maxi-K) potassium channels |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(C(F)(F)F)ccc21 |
Identifiers
| PDB | — |
| CAS-ID | 183720-28-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL266510 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | J57O328W4W (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNQ4
KCNQ4
KCNMA1
KCNMA1
KCNQ5
KCNQ5
KCNQ2
KCNQ2
Organism
Homo sapiens
Gene name
KCNQ4
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily KQT member 4
Protein synonyms
KQT-like 4, potassium channel KQT-like 4, Potassium channel subunit alpha KvLQT4, potassium channel, voltage gated KQT-like subfamily Q, member 4, potassium voltage-gated channel, KQT-like subfamily, member 4, Voltage-gated potassium channel subunit Kv7.4
Uniprot ID
Mouse ortholog
Kcnq4 (60613)
potassium voltage-gated channel subfamily KQT member 4 (Q9JK97)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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