Skip to content
Fluphenazine
Permitil, Prolixin (fluphenazine) is a small molecule pharmaceutical. Fluphenazine was first approved as Prolixin decanoate on 1982-01-01. It is used to treat psychotic disorders and schizophrenia in the USA. The pharmaceutical is active against D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 6, D(1A) dopamine receptor, D(1B) dopamine receptor, histamine H1 receptor, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 2A.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fluphenazine decanoate
Tradename
Company
Number
Date
Products
PROLIXIN DECANOATEBristol Myers SquibbN-016727 DISCN1982-01-01
1 products, RLD
Hide discontinued
Fluphenazine enanthate
Tradename
Company
Number
Date
Products
PROLIXIN ENANTHATEBristol Myers SquibbN-016110 DISCN1982-01-01
1 products
Hide discontinued
Fluphenazine hydrochloride
Tradename
Company
Number
Date
Products
PROLIXINBristol Myers SquibbN-011751 DISCN1982-01-01
5 products
PROLIXINBristol Myers SquibbN-012145 DISCN1982-01-01
1 products, RLD
PERMITILMerck Sharp & DohmeN-012034 DISCN1982-01-01
4 products
PERMITILMerck Sharp & DohmeN-012419 DISCN1982-01-01
1 products
PERMITILMerck Sharp & DohmeN-016008 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
fluphenazine hydrochlorideANDA2023-05-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
psychotic disorders—D011618F20.81
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AB: Phenothiazines with piperazine structure, antipsychotics
— N05AB02: Fluphenazine
HCPCS
Code
Description
J2680
Injection, fluphenazine decanoate, up to 25 mg
Clinical
Clinical Trials
10 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20——2215
Psychotic disordersD011618F20.81———1—1
Schizophrenia spectrum and other psychotic disordersD019967———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PsoriasisD011565EFO_0000676L40—2———2
GamblingD005715F63.0—1———1
Plasma cell neoplasmsD05421911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.01————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameFLUPHENAZINE
INNfluphenazine
Description
Fluphenazine is a member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an anticoronaviral agent. It is an organofluorine compound, a member of phenothiazines and a N-alkylpiperazine. It derives from a hydride of a 10H-phenothiazine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
Identifiers
PDB—
CAS-ID69-23-8
RxCUI4496
ChEMBL IDCHEMBL726
ChEBI ID5123
PubChem CID3372
DrugBankDB00623
UNII IDS79426A41Z (ChemIDplus, GSRS)
Target
Agency Approved
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD2
Gene synonyms
NCBI Gene ID
1813
Protein name
D(2) dopamine receptor
Protein synonyms
Dopamine D2 receptor, seven transmembrane helix receptor
Uniprot ID
Q9UPA9
Mouse ortholog
Drd2 (13489)
D(2) dopamine receptor (Q0VGH9)
Alternate
HTR6
HTR6
DRD1
DRD1
DRD5
DRD5
HRH1
HRH1
HTR7
HTR7
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
3362
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Q5TGZ1
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 3,889 documents
View more details
Safety
Black-box Warning
Black-box warning for: Fluphenazine hydrochloride
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
19,148 adverse events reported
View more details