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Fluspirilene
Fluspirilene is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1D, histamine H1 receptor, and 5-hydroxytryptamine receptor 1A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AG: Diphenylbutylpiperidine derivatives, antipsychotics
— N05AG01: Fluspirilene
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20——11—2
Psychotic disordersD011618F20.81———112
Schizophrenia spectrum and other psychotic disordersD019967———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic renal insufficiencyD051436N18————11
Type 2 diabetes mellitusD003924EFO_0001360E11————11
Acute coronary syndromeD054058EFO_0005672————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFLUSPIRILENE
INNfluspirilene
Description
8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a diarylmethane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1NCN(c2ccccc2)C12CCN(CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2
Identifiers
PDB—
CAS-ID1841-19-6
RxCUI4507
ChEMBL IDCHEMBL46516
ChEBI ID—
PubChem CID3396
DrugBankDB04842
UNII IDC5QA4GLR9M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR1E
HTR1E
HTR2A
HTR2A
HTR1D
HTR1D
HRH1
HRH1
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR1E
Gene synonyms
NCBI Gene ID
3354
Protein name
5-hydroxytryptamine receptor 1E
Protein synonyms
5-HT-1E, 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled, S31, Serotonin receptor 1E
Uniprot ID
Q9P1Y1
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 353 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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20 adverse events reported
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