Fosbretabulin
Fosbretabulin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 3 | 1 | — | — | 3 |
| Anaplastic thyroid carcinoma | D065646 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 3 | 2 | — | — | — | 5 | |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 2 | — | — | — | 3 |
| Head and neck neoplasms | D006258 | 1 | 2 | — | — | — | 2 | ||
| Choroidal neovascularization | D020256 | 1 | 2 | — | — | — | 2 | ||
| Fallopian tube neoplasms | D005185 | — | 1 | — | — | — | 1 | ||
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | 1 | — | — | — | 1 |
| Degenerative myopia | D047728 | H44.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FOSBRETABULIN |
| INN | fosbretabulin |
| Description | Fosbretabulin (also known as combretastatin A-4 phosphate or CA4P) is a microtubule destabilizing experimental drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumours causing central necrosis. It is a derivative of combretastatin. It is formulated as the salts fosbretabulin disodium and fosbretabulin tromethamine.
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| Classification | Small molecule |
| Drug class | antineoplastics (mitotic inhibitors; tubulin binders); phosphoro-derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(/C=C\c2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 222030-63-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1206232 |
| ChEBI ID | — |
| PubChem CID | 5351387 |
| DrugBank | DB12577 |
| UNII ID | I5590ES2QZ (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 342 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
0 adverse events reported
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