Skip to content
Fosinopril
Monopril, Monopril-hct (fosinopril) is a small molecule pharmaceutical. Fosinopril was first approved as Monopril on 1991-05-16. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fosinopril sodium
Tradename
Company
Number
Date
Products
MONOPRILBristol Myers SquibbN-019915 DISCN1991-05-16
3 products, RLD
Hide discontinued
Fosinopril sodium
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
MONOPRIL-HCTBristol Myers SquibbN-020286 DISCN1994-11-30
2 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
fosinopril sodiumANDA2023-06-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diabetic nephropathiesEFO_0000401D003928—
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
left ventricular dysfunction—D018487—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA09: Fosinopril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA09: Fosinopril and diuretics
HCPCS
No data
Clinical
Clinical Trials
29 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B207442623
Cytomegalovirus retinitisD017726EFO_10013022421413
Cytomegalovirus infectionsD003586EFO_0001062B25———213
HypocalcemiaD006996HP_0002901E83.51———1—1
Hematologic diseasesD006402EFO_0005803D75.9———1—1
Herpes zosterD006562EFO_0006510B02———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Herpes simplexD006561B001—1—24
Acquired immunodeficiency syndromeD000163EFO_0000765B20——1——1
Papillomavirus infectionsD030361——1——1
Gastrointestinal diseasesD005767——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Graft vs host diseaseD006086D89.81—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Brain diseasesD001927HP_0001298G93.401————1
RadiculopathyD011843M54.11————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D46————11
Myeloid leukemia acuteD015470C92.0————11
Non-hodgkin lymphomaD008228C85.9————11
Extranodal nk-t-cell lymphomaD054391C86.0————11
Essential thrombocythemiaD013920D47.3————11
Polycythemia veraD011087D45————11
Primary myelofibrosisD055728D47.4————11
Multiple myelomaD009101C90.0————11
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0————11
B-cell chronic lymphocytic leukemiaD015451C91.1————11
Show 26 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameFOSINOPRIL
INNfosinopril
Description
Fosinopril is a phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a phosphinic ester and a L-proline derivative. It is functionally related to a fosinoprilat. It is a conjugate acid of a fosinopril(1-).
Classification
Small molecule
Drug classphosphoro-derivatives; antihypertensives (ACE inhibitors)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C
Identifiers
PDB—
CAS-ID1217600-34-4
RxCUI—
ChEMBL IDCHEMBL3039598
ChEBI ID—
PubChem CID55891
DrugBankDB00492
UNII IDR43D2573WO (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
1636
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Q7M4L4
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 1,746 documents
View more details
Safety
Black-box Warning
Black-box warning for: Fosinopril sodium
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
1,889 adverse events reported
View more details