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Fosmidomycin
Fosmidomycin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
No data
HCPCS
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B54—51——6
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Falciparum malariaD016778EFO_0007444B50—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFOSMIDOMYCIN
INNfosmidomycin
Description
Fosmidomycin is propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It has a role as an antimicrobial agent, an EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor and a bacterial metabolite. It is a member of phosphonic acids and a hydroxamic acid.
Classification
Small molecule
Drug classphosphoro-derivatives; antibiotics (Streptomyces strain)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=CN(O)CCCP(=O)(O)O
Identifiers
PDB—
CAS-ID66508-53-0
RxCUI—
ChEMBL IDCHEMBL203125
ChEBI ID443725
PubChem CID572
DrugBankDB02948
UNII ID5829E3D9I9 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DXR
DXR
Organism
Plasmodium falciparum 3D7
Gene name
DXR
Gene synonyms
NCBI Gene ID
812223
Protein name
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Protein synonyms
MEP synthase
Uniprot ID
Q8IKG4
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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