Cytovene, Vitrasert implant(ganciclovir)
Cytovene, Ganzyk-rtu, Vitrasert Implant, Zirgan (ganciclovir) is a small molecule pharmaceutical. Ganciclovir was first approved as Cytovene on 1989-06-23. It is used to treat aids-related opportunistic infections, cytomegalovirus infections, and cytomegalovirus retinitis in the USA. It has been approved in Europe to treat cytomegalovirus retinitis and HIV infections.
Download report
Favorite
Searched
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
---|---|
infections | D007239 |
eye diseases | D005128 |
urogenital diseases | D000091642 |
immune system diseases | D007154 |
Trade Name
FDA
EMA
Ganzyk-rtu, Zirgan (generic drugs available since 2003-07-16, discontinued: Cytovene, Vitrasert)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ganciclovir
Ganciclovir sodium
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CYTOVENE | CHEPLAPHARM Arzneimittel | N-019661 DISCN | 1989-06-23 | 1 products, RLD |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
---|---|---|
ganciclovir | ANDA | 2022-12-21 |
zirgan | New Drug Application | 2019-09-03 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
aids-related opportunistic infections | — | D017088 | — |
cytomegalovirus infections | EFO_0001062 | D003586 | B25 |
cytomegalovirus retinitis | EFO_1001302 | D017726 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Ganciclovir, Ganzyk-Rtu, Exela Pharma | |||
9486530 | 2034-09-02 | DP |
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
— J05AB06: Ganciclovir
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AD: Antivirals, ophthalmologic
— S01AD09: Ganciclovir
HCPCS
Code | Description |
---|---|
J1570 | Injection, ganciclovir sodium, 500 mg |
J7310 | Ganciclovir, 4.5 mg, long-acting implant |
Level 3: J7310-J7310 | Ganciclovir |
Clinical
Clinical Trials
100 clinical trials
View more details
![](https://www.pharmakb.com/hubfs/raw_assets/public/ccd-theme/images/generated-html-images/trials-plot.png)
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hiv infections | D015658 | EFO_0000764 | B20 | 8 | 4 | 7 | 1 | 17 | 37 |
Cytomegalovirus retinitis | D017726 | EFO_1001302 | 4 | 4 | 7 | 1 | 12 | 28 | |
Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | 4 | 2 | 6 | 6 | 9 | 25 |
Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | — | 2 | |
Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | 1 | — | 1 |
Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | — | — | 1 | — | 1 |
Keratoconjunctivitis | D007637 | H16.2 | — | — | — | 1 | — | 1 | |
Virus shedding | D017201 | — | — | — | 1 | — | 1 | ||
Viremia | D014766 | B34.9 | — | — | — | 1 | — | 1 | |
Herpesviridae infections | D006566 | EFO_0007309 | B00.4 | — | — | — | 1 | — | 1 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 1 | 1 | — | — | 2 |
Conjunctivitis | D003231 | H10 | — | — | 1 | — | — | 1 | |
Adenoviridae | D000256 | — | — | 1 | — | — | 1 | ||
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lymphoma | D008223 | C85.9 | 2 | 3 | — | — | 1 | 6 | |
Leukemia | D007938 | C95 | 1 | 1 | — | — | 1 | 3 | |
Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | 1 | — | — | — | 2 |
Falciparum malaria | D016778 | EFO_0007444 | B50 | 2 | 1 | — | — | — | 2 |
Multiple myeloma | D009101 | C90.0 | — | 1 | — | — | 1 | 2 | |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | — | 2 |
Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | — | 1 |
Kidney transplantation | D016030 | 1 | 1 | — | — | — | 1 | ||
Graft vs host disease | D006086 | D89.81 | — | 1 | — | — | — | 1 | |
Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colitis | D003092 | EFO_0003872 | K52.9 | 1 | — | — | — | 1 | 2 |
Neuroblastoma | D009447 | EFO_0000621 | 1 | — | — | — | — | 1 | |
Precancerous conditions | D011230 | 1 | — | — | — | — | 1 | ||
Malignant mesothelioma | D000086002 | 1 | — | — | — | — | 1 | ||
Melanoma | D008545 | 1 | — | — | — | — | 1 | ||
Central nervous system neoplasms | D016543 | 1 | — | — | — | — | 1 | ||
Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
Neoplasm metastasis | D009362 | EFO_0009708 | 1 | — | — | — | — | 1 | |
Brain diseases | D001927 | HP_0001298 | G93.40 | 1 | — | — | — | — | 1 |
Radiculopathy | D011843 | M54.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | D46 | — | — | — | — | 2 | 2 | |
Cerebral hemorrhage | D002543 | — | — | — | — | 1 | 1 | ||
Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 1 | 1 |
Drug monitoring | D016903 | — | — | — | — | 1 | 1 | ||
Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | — | 1 | 1 |
Virus diseases | D014777 | B34 | — | — | — | — | 1 | 1 | |
Posterior uveitis | D015866 | EFO_1001119 | — | — | — | — | 1 | 1 | |
Herpetic keratitis | D016849 | EFO_0007308 | — | — | — | — | 1 | 1 | |
Anterior uveitis | D014606 | EFO_1000811 | — | — | — | — | 1 | 1 | |
Viral conjunctivitis | D003236 | EFO_0008571 | B30 | — | — | — | — | 1 | 1 |
Show 38 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common name | GANCICLOVIR |
INN | ganciclovir |
Description | Ganciclovir, sold under the brand name Cytovene among others, is an antiviral medication used to treat cytomegalovirus (CMV) infections.
|
Classification | Small molecule |
Drug class | antivirals: antivirals (acyclovir type) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | Nc1nc2c(ncn2COC(CO)CO)c(=O)[nH]1 |
Identifiers
PDB | — |
CAS-ID | 82410-32-0 |
RxCUI | 4678 |
ChEMBL ID | CHEMBL182 |
ChEBI ID | 465284 |
PubChem CID | 3454 |
DrugBank | DB01004 |
UNII ID | P9G3CKZ4P5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
![](https://www.pharmakb.com/hubfs/raw_assets/public/ccd-theme/images/generated-html-images/top-terms-plot.png)
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 16,823 documents
View more details
Safety
Black-box Warning
Black-box warning for: Ganciclovir
Adverse Events
Top Adverse Reactions
![](https://www.pharmakb.com/hubfs/raw_assets/public/ccd-theme/images/generated-html-images/top-adverse-reactions-plot.png)
Mock data
Subscribe for the real data
Subscribe for the real data
6 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more