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Gandotinib
Gandotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK2. In addition, it is known to target tyrosine-protein kinase JAK3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hematologic neoplasmsD019337—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Essential thrombocythemiaD013920D47.32————2
Polycythemia veraD011087D452————2
Primary myelofibrosisD055728D47.42————2
Myeloproliferative disordersD009196D47.11————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGANDOTINIB
INNgandotinib
Description
Gandotinib is a member of pyridazines.
Classification
Small molecule
Drug classtyrosine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(Nc2cc(CN3CCOCC3)c3nc(C)c(Cc4ccc(Cl)cc4F)n3n2)n[nH]1
Identifiers
PDB—
CAS-ID1229236-86-5
RxCUI—
ChEMBL IDCHEMBL2107823
ChEBI ID—
PubChem CID46213929
DrugBankDB13040
UNII IDANC71R916O (ChemIDplus, GSRS)
Target
Agency Approved
JAK2
JAK2
Organism
Homo sapiens
Gene name
JAK2
Gene synonyms
NCBI Gene ID
3717
Protein name
tyrosine-protein kinase JAK2
Protein synonyms
JAK-2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase)
Uniprot ID
O75297
Mouse ortholog
Jak2 (16452)
tyrosine-protein kinase JAK2 (Q7TQD0)
Alternate
JAK3
JAK3
Organism
Homo sapiens
Gene name
JAK3
Gene synonyms
NCBI Gene ID
3718
Protein name
tyrosine-protein kinase JAK3
Protein synonyms
JAK-3, Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), L-JAK, Leukocyte janus kinase
Uniprot ID
Q9Y6S2
Mouse ortholog
Jak3 (16453)
tyrosine-protein kinase JAK3 (Q62137)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 72 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6 adverse events reported
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