Gefapixant
Gefapixant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target P2X purinoceptor 3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Idiopathic pulmonary fibrosis | D054990 | J84.112 | — | 2 | — | — | — | 2 | |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
| Cough | D003371 | HP_0012735 | R05 | — | 1 | — | — | — | 1 |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | — | 3 | ||
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GEFAPIXANT |
| INN | gefapixant |
| Description | Gefapixant (MK-7264) is a drug which acts as an antagonist of the P2RX3 receptor, and may be useful in the treatment of chronic cough. It was named in honour of Geoff Burnstock.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 1015787-98-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3716057 |
| ChEBI ID | — |
| PubChem CID | 24764487 |
| DrugBank | DB15097 |
| UNII ID | 6K6L7E3F1L (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
P2RX3
P2RX3
Organism
Homo sapiens
Gene name
P2RX3
Gene synonyms
NCBI Gene ID
Protein name
P2X purinoceptor 3
Protein synonyms
ATP receptor, P2X receptor, subunit 3, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 3, purinergic receptor P2X3, purinoceptor P2X3
Uniprot ID
Mouse ortholog
P2rx3 (228139)
P2X purinoceptor 3 (Q8R1U4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 208 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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