Genistein
Genistein is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target estrogen-related receptor gamma, steroid hormone receptor ERR1, cystic fibrosis transmembrane conductance regulator, estrogen receptor beta, short transient receptor potential channel 5, and steroid hormone receptor ERR2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
44 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | C61 | 2 | 7 | 1 | — | 2 | 10 | |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | 2 | 1 | — | 1 | 4 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | 2 | 2 | — | 1 | 3 |
| Metabolic bone diseases | D001851 | HP_0000938 | 1 | 1 | 1 | — | 1 | 3 | |
| Menopause | D008593 | EFO_0003922 | N95 | — | 1 | 1 | — | 1 | 2 |
| Coronary artery disease | D003324 | I25.1 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 3 | 3 | — | — | — | 4 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 3 | — | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | 2 | 2 | — | — | — | 2 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Lymphoma | D008223 | C85.9 | 1 | 1 | — | — | — | 2 | |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 2 | 2 | — | — | — | 2 |
| Melanoma | D008545 | 2 | 1 | — | — | — | 2 | ||
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 2 | 1 | — | — | — | 2 |
| Postmenopause | D017698 | — | 1 | — | — | 1 | 2 | ||
| Urinary bladder neoplasms | D001749 | C67 | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute radiation syndrome | D054508 | 2 | — | — | — | — | 2 | ||
| Endometrial neoplasms | D016889 | EFO_0004230 | 1 | — | — | — | — | 1 | |
| Leukemia | D007938 | C95 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GENISTEIN |
| INN | genistein |
| Description | Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a phytoestrogen, a plant metabolite, a geroprotector and a human urinary metabolite. It is a conjugate acid of a genistein(1-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 |
Target
Agency Approved
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Alternate
ESRRG
ESRRG
ESRRA
ESRRA
CFTR
CFTR
ESR2
ESR2
TRPC5
TRPC5
ESRRB
ESRRB
Organism
Homo sapiens
Gene name
ESRRG
Gene synonyms
ERR3, ERRG2, KIAA0832, NR3B3
NCBI Gene ID
Protein name
estrogen-related receptor gamma
Protein synonyms
ERR gamma-2, Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3
Uniprot ID
Mouse ortholog
Esrrg (26381)
estrogen-related receptor gamma (P62509)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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