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Givinostat
Givinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 2, histone deacetylase 1, histone deacetylase 6, histone deacetylase 8, histone deacetylase 5, histone deacetylase 7, histone deacetylase 3, histone deacetylase 9, and histone deacetylase 4.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
12 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Duchenne muscular dystrophyD020388132——4
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Polycythemia veraD011087D4512———2
Juvenile arthritisD001171EFO_0002609M08—1——12
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD0043471————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGIVINOSTAT
INNgivinostat
Description
N-[4-[(hydroxyamino)-oxomethyl]phenyl]carbamic acid [6-(diethylaminomethyl)-2-naphthalenyl]methyl ester is a carbamate ester.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors; vinca alkaloids
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(C(=O)NO)cc3)ccc2c1
Identifiers
PDB6UOC
CAS-ID497833-27-9
RxCUI—
ChEMBL IDCHEMBL1213492
ChEBI ID—
PubChem CID9804992
DrugBankDB12645
UNII ID5P60F84FBH (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HDAC2
HDAC2
HDAC1
HDAC1
HDAC6
HDAC6
HDAC8
HDAC8
HDAC5
HDAC5
HDAC7
HDAC7
HDAC3
HDAC3
HDAC9
HDAC9
HDAC4
HDAC4
Organism
Homo sapiens
Gene name
HDAC2
Gene synonyms
NCBI Gene ID
3066
Protein name
histone deacetylase 2
Protein synonyms
Protein deacylase HDAC2, transcriptional regulator homolog RPD3, YY1-associated factor 1
Uniprot ID
Q92769
Mouse ortholog
Hdac2 (15182)
histone deacetylase 2 (P70288)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 786 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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