Mavyret, Maviret(glecaprevir)
Maviret, Mavyret (glecaprevir) is a small molecule pharmaceutical. Glecaprevir was first approved as Maviret on 2017-07-26. It is used to treat hepatitis c in the USA. It has been approved in Europe to treat chronic hepatitis c.
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Combinations
Mavyret
Drug Products
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Brand Name | Status | Last Update |
|---|---|---|
| mavyret | New Drug Application | 2020-05-08 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
GLECAPREVIR / PIBRENTASVIR, MAVYRET, ABBVIE | |||
| 2028-12-10 | PED | ||
| 2028-06-10 | ODE-372 | ||
| 2026-10-30 | PED | ||
| 2026-04-30 | ODE-232, ODE-233 | ||
| 2023-10-10 | PED | ||
| 2023-04-10 | M-259 | ||
| 2023-03-26 | PED | ||
| 2023-02-03 | PED | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Glecaprevir / Pibrentasvir, Mavyret, Abbvie | |||
| 11246866 | 2036-06-24 | DP | |
| 9321807 | 2035-06-05 | DP | |
| RE48923 | 2035-05-08 | DP | |
| 10286029 | 2034-03-14 | U-3237, U-3238 | |
| 11484534 | 2034-03-14 | U-3237 | |
| 8937150 | 2032-05-18 | DS, DP | |
| 8648037 | 2032-01-19 | DS, DP | U-2141, U-3237, U-3238 |
| 9586978 | 2030-11-06 | U-2141, U-3237, U-3238 | |
| 10028937 | 2030-06-10 | U-2141, U-3237, U-3238 | |
| 10039754 | 2030-06-10 | U-2141, U-3237, U-3238 | |
HCPCS
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Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | B19.2 | 1 | 7 | 16 | 11 | 5 | 35 | |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 4 | 12 | 2 | 1 | 17 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 2 | 1 | — | 4 | — | 6 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | 2 | — | 3 |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | 2 | — | 2 | |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | — | 1 | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | — | 1 |
| Heroin dependence | D006556 | EFO_0004240 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepacivirus | D016174 | — | 4 | 8 | — | — | 10 | ||
| Hepatitis b | D006509 | 1 | 1 | 3 | — | 1 | 5 | ||
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 2 | — | 1 | 4 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 2 | 2 | — | — | 2 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatic insufficiency | D048550 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | — | — | 1 | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | — | 1 | 1 |
| Rna virus infections | D012327 | — | — | — | — | 1 | 1 | ||
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | — | — | — | 1 | 1 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | — | — | 1 | 1 |
| Viral hepatitis human | D006525 | EFO_0004196 | — | — | — | — | 1 | 1 | |
| Coronary artery disease | D003324 | I25.1 | — | — | — | — | 1 | 1 | |
| Morals | D009014 | — | — | — | — | 1 | 1 | ||
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | — | 1 | 1 |
| Hiv | D006678 | O98.7 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GLECAPREVIR |
| INN | glecaprevir |
| Description | Glecaprevir (INN,) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that was identified jointly by AbbVie and Enanta Pharmaceuticals. It is being developed as a treatment of chronic hepatitis C infection in co-formulation with an HCV NS5A inhibitor pibrentasvir. Together they demonstrated potent antiviral activity against major HCV genotypes and high barriers to resistance in vitro.
|
| Classification | Small molecule |
| Drug class | antivirals: serine protease inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)[C@@H]1NC(=O)O[C@@H]2CCC[C@H]2OC/C=C/C(F)(F)c2nc3ccccc3nc2O[C@@H]2C[C@@H](C(=O)N[C@]3(C(=O)NS(=O)(=O)C4(C)CC4)C[C@H]3C(F)F)N(C2)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 1365970-03-1 |
| RxCUI | 1940635 |
| ChEMBL ID | CHEMBL3545363 |
| ChEBI ID | — |
| PubChem CID | 66828839 |
| DrugBank | DB13879 |
| UNII ID | K6BUU8J72P (ChemIDplus, GSRS) |
Target
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Alternate
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Variants
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Financial
Mavyret - AbbVie
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Safety
Black-box Warning
Black-box warning for: Mavyret
Adverse Events
Top Adverse Reactions
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2,981 adverse events reported
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