Grepafloxacin
Raxar (grepafloxacin) is a small molecule pharmaceutical. Grepafloxacin was first approved as Raxar on 1997-11-06.
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Grepafloxacin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RAXAR | Otsuka | N-020695 DISCN | 1997-11-06 | 3 products |
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30 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental pulp necrosis | D003790 | K04.1 | 3 | — | — | 1 | — | 4 | |
| Periapical abscess | D010482 | EFO_1001202 | — | — | — | 1 | — | 1 | |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hordeolum | D006726 | EFO_0007315 | H00.01 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | — | — | 1 | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asymptomatic diseases | D058070 | 1 | — | — | — | — | 1 | ||
| Regeneration | D012038 | 1 | — | — | — | — | 1 | ||
| Covid-19 | D000086382 | U07.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Pituitary neoplasms | D010911 | — | — | — | — | 1 | 1 | ||
| Uterine rupture | D014597 | — | — | — | — | 1 | 1 | ||
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | — | — | 1 | 1 |
| Zenker diverticulum | D016672 | EFO_1001867 | — | — | — | — | 1 | 1 | |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | — | — | — | 1 | 1 |
| Burns | D002056 | T30.0 | — | — | — | — | 1 | 1 | |
| Aortic valve stenosis | D001024 | EFO_0000266 | Q25.1 | — | — | — | — | 1 | 1 |
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Epidemiology
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Drug
General
| Drug common name | GREPAFLOXACIN |
| INN | grepafloxacin |
| Description | Grepafloxacin (trade name Raxar, Glaxo Wellcome) was an oral broad-spectrum fluoroquinolone antibacterial agent used to treat bacterial infections. Grepafloxacin was withdrawn worldwide from markets in 1999, due to its side effect of lengthening the QT interval on the electrocardiogram, leading to cardiac events and sudden death.
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| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1 |
Identifiers
| PDB | — |
| CAS-ID | 119914-60-2 |
| RxCUI | 83719 |
| ChEMBL ID | CHEMBL583 |
| ChEBI ID | 5543 |
| PubChem CID | 72474 |
| DrugBank | DB00365 |
| UNII ID | L1M1U2HC31 (ChemIDplus, GSRS) |
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1,297 adverse events reported
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