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Guanabenz
Wytensin (guanabenz) is a small molecule pharmaceutical. Guanabenz was first approved as Wytensin on 1982-09-07. It is used to treat hypertension in the USA. The pharmaceutical is active against alpha-2A adrenergic receptor, alpha-2B adrenergic receptor, and alpha-2C adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Guanabenz acetate
Tradename
Company
Number
Date
Products
WYTENSINWyethN-018587 DISCN1982-09-07
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGUANABENZ
INNguanabenz
Description
Guanabenz is a dichlorobenzene.
Classification
Small molecule
Drug classantihypertensives (guanidine deriviatives); cannabinol derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)N/N=C/c1c(Cl)cccc1Cl
Identifiers
PDB—
CAS-ID5051-62-7
RxCUI5033
ChEMBL IDCHEMBL420
ChEBI ID5553
PubChem CID5702063
DrugBankDB00629
UNII IDGGD30112WC (ChemIDplus, GSRS)
Target
Agency Approved
ADRA2A
ADRA2A
ADRA2B
ADRA2B
ADRA2C
ADRA2C
Organism
Homo sapiens
Gene name
ADRA2A
Gene synonyms
ADRA2R, ADRAR
NCBI Gene ID
150
Protein name
alpha-2A adrenergic receptor
Protein synonyms
adrenergic, alpha-2A-, receptor, Alpha-2 adrenergic receptor subtype C10, alpha-2-adrenergic receptor, platelet type, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, alpha-2AAR subtype C10
Uniprot ID
Q9BZK1
Mouse ortholog
Adra2a (11551)
alpha-2A adrenergic receptor (Q3URE6)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 919 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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