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Guanethidine
Esimil, Ismelin (guanethidine) is a small molecule pharmaceutical. Guanethidine was first approved as Ismelin on 1982-01-01. It is used to treat hypertension in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Guanethidine monosulfate
Tradename
Company
Number
Date
Products
ISMELINNovartisN-012329 DISCN1982-01-01
2 products
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Guanethidine monosulfate
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Hydrochlorothiazide
Tradename
Company
Number
Date
Products
ESIMILNovartisN-013553 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02C: Antiadrenergic agents, peripherally acting
— C02CC: Guanine derivatives, peripherally acting antiadrenergic agents
— C02CC02: Guanethidine
— C02L: Antihypertensives and diuretics in combination
— C02LF: Guanidine derivatives and diuretics
— C02LF01: Guanethidine and diuretics
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EX: Other antiglaucoma preparations in atc
— S01EX01: Guanethidine
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGUANETHIDINE
INNguanethidine
Description
Guanethidine is a member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group. It has a role as an antihypertensive agent, an adrenergic antagonist and a sympatholytic agent. It is a member of guanidines and a member of azocanes. It is functionally related to a guanidine. It derives from a hydride of an azocane.
Classification
Small molecule
Drug classantihypertensives (guanidine deriviatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)NCCN1CCCCCCC1
Identifiers
PDB—
CAS-ID55-65-2
RxCUI5036
ChEMBL IDCHEMBL765
ChEBI ID5557
PubChem CID3518
DrugBankDB01170
UNII IDZTI6C33Q2Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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