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Guanidine
Guanidine is a small molecule pharmaceutical. Guanidine was first approved as Guanidine hydrochloride on 1982-01-01. It is used to treat lambert-eaton myasthenic syndrome and muscle weakness in the USA. It is known to target acid-sensing ion channel 3 and nitric oxide synthase, inducible.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
musculoskeletal diseasesD009140
nervous system diseasesD009422
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Guanidine hydrochloride
Tradename
Company
Number
Date
Products
GUANIDINE HYDROCHLORIDEMerck Sharp & DohmeN-001546 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
lambert-eaton myasthenic syndromeEFO_0020094D015624G70.80
muscle weaknessHP_0001324D018908—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02L: Antihypertensives and diuretics in combination
— C02LF: Guanidine derivatives and diuretics
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGUANIDINE
INN—
Description
Guanidine is an aminocarboxamidine, the parent compound of the guanidines. It is a one-carbon compound, a member of guanidines and a carboxamidine. It is a conjugate base of a guanidinium.
Classification
Small molecule
Drug classantihypertensives (guanidine deriviatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)N
Identifiers
PDB—
CAS-ID113-00-8
RxCUI50675
ChEMBL IDCHEMBL821
ChEBI ID42820
PubChem CID3520
DrugBankDB00536
UNII ID—
Target
Agency Approved
No data
Alternate
ASIC3
ASIC3
NOS2
NOS2
Organism
Homo sapiens
Gene name
ASIC3
Gene synonyms
ACCN3, SLNAC1, TNAC1
NCBI Gene ID
9311
Protein name
acid-sensing ion channel 3
Protein synonyms
acid sensing (proton gated) ion channel 3, Amiloride-sensitive cation channel 3, amiloride-sensitive cation channel 3, testis, hTNaC1, modulatory subunit of ASIC2a, Neuronal amiloride-sensitive cation channel 3, proton-gated cation channel subunit, Testis sodium channel 1
Uniprot ID
Q9UHC4
Mouse ortholog
Asic3 (171209)
acid-sensing ion channel 3 (Q6X1Y6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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12 adverse events reported
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