Guanidine
Guanidine is a small molecule pharmaceutical. Guanidine was first approved as Guanidine hydrochloride on 1982-01-01. It is used to treat lambert-eaton myasthenic syndrome and muscle weakness in the USA. It is known to target acid-sensing ion channel 3 and nitric oxide synthase, inducible.
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Guanidine hydrochloride
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
GUANIDINE HYDROCHLORIDE | Merck Sharp & Dohme | N-001546 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
lambert-eaton myasthenic syndrome | EFO_0020094 | D015624 | G70.80 |
muscle weakness | HP_0001324 | D018908 | — |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common name | GUANIDINE |
INN | — |
Description | Guanidine is an aminocarboxamidine, the parent compound of the guanidines. It is a one-carbon compound, a member of guanidines and a carboxamidine. It is a conjugate base of a guanidinium. |
Classification | Small molecule |
Drug class | antihypertensives (guanidine deriviatives) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | N=C(N)N |
Target
Agency Approved
No data
Alternate
ASIC3
ASIC3
NOS2
NOS2
Organism
Homo sapiens
Gene name
ASIC3
Gene synonyms
ACCN3, SLNAC1, TNAC1
NCBI Gene ID
Protein name
acid-sensing ion channel 3
Protein synonyms
acid sensing (proton gated) ion channel 3, Amiloride-sensitive cation channel 3, amiloride-sensitive cation channel 3, testis, hTNaC1, modulatory subunit of ASIC2a, Neuronal amiloride-sensitive cation channel 3, proton-gated cation channel subunit, Testis sodium channel 1
Uniprot ID
Mouse ortholog
Asic3 (171209)
acid-sensing ion channel 3 (Q6X1Y6)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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12 adverse events reported
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