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Hexachlorophene
Pre-op (hexachlorophene) is a small molecule pharmaceutical. Hexachlorophene was first approved as Scrubteam surgical spongebrush on 1982-01-01. It is used to treat acne vulgaris and communicable diseases in the USA. It is known to target N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Pre-op (discontinued: Dial, E-z scrub, Gamophen, Germa-medica, Germa-medica mg, Hexa-germ, Hexascrub, Phiso-scrub, Phisohex, Scrubteam surgical spongebrush, Septi-soft, Septisol, Soy-dome, Turgex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hexachlorophene
Tradename
Company
Number
Date
Products
PRE-OPDavis & GeckN-017433 RX1982-01-01
1 products, RLD, RS
PRE-OP IIDavis & GeckN-017433 RX1982-01-01
1 products, RLD
Show 17 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bd e-z scrubOTC monograph not final2022-05-18
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
communicable diseases—D003141—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AE: Phenol and derivatives, antiseptics and disinfectants
— D08AE01: Hexachlorophene
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHEXACHLOROPHENE
INNhexachlorophene
Description
Hexachlorophene is an organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. It has a role as an antiseptic drug, an acaricide, an antibacterial agent and an antifungal agrochemical. It is a polyphenol, a trichlorobenzene and a bridged diphenyl fungicide.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl
Identifiers
PDB—
CAS-ID70-30-4
RxCUI5293
ChEMBL IDCHEMBL496
ChEBI ID5693
PubChem CID3598
DrugBankDB00756
UNII IDIWW5FV6NK2 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NAPEPLD
NAPEPLD
Organism
Homo sapiens
Gene name
NAPEPLD
Gene synonyms
C7orf18
NCBI Gene ID
222236
Protein name
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Protein synonyms
NAPE-hydrolyzing phospholipase D
Uniprot ID
Q769K1
Mouse ortholog
Napepld (242864)
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (Q8BH82)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 10,084 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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