Skip to content
Histamine phosphate, Ceplene(histamine)
Ceplene (histamine) is a small molecule pharmaceutical. Histamine was first approved as Histamine phosphate on 1982-01-01. It is used to treat allergic rhinitis seasonal and urticaria in the USA. It has been approved in Europe to treat myeloid leukemia acute. It is known to target histamine H4 receptor, histamine H1 receptor, histamine H3 receptor, carbonic anhydrase 7, histamine H2 receptor, carbonic anhydrase 5A, mitochondrial, and carbonic anhydrase 1.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Histamine phosphate
Tradename
Company
Number
Date
Products
HISTAMINE PHOSPHATEEli LillyN-000734 DISCN1982-01-01
3 products
Hide discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis seasonalEFO_0003956D006255J30
urticariaEFO_0005531D014581L50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L03: Immunostimulants
— L03A: Immunostimulants
— L03AX: Other immunostimulants in atc
— L03AX14: Histamine dihydrochloride
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CG: Gastric secretion test diagnostic agents
— V04CG03: Histamine phosphate
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameHISTAMINE
INN—
Description
Histamine is a member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is an aralkylamino compound and a member of imidazoles. It is a conjugate base of a histaminium.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NCCc1c[nH]cn1
Identifiers
PDB6FU4
CAS-ID51-45-6
RxCUI5333
ChEMBL IDCHEMBL90
ChEBI ID18295
PubChem CID774
DrugBankDB05381
UNII ID—
Target
Agency Approved
No data
Alternate
HRH4
HRH4
HRH1
HRH1
HRH3
HRH3
CA7
CA7
HRH2
HRH2
CA5A
CA5A
CA1
CA1
Organism
Homo sapiens
Gene name
HRH4
Gene synonyms
GPCR105
NCBI Gene ID
59340
Protein name
histamine H4 receptor
Protein synonyms
AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144
Uniprot ID
Q9H3N8
Mouse ortholog
Hrh4 (225192)
histamine H4 receptor (Q91ZY2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 93,174 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details