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Histidine
Histidine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target pituitary adenylate cyclase-activating polypeptide type I receptor, solute carrier family 15 member 4, vasoactive intestinal polypeptide receptor 2, secretin receptor, carbonic anhydrase 7, carbonic anhydrase 5A, mitochondrial, carbonic anhydrase 1, sodium-coupled neutral amino acid transporter 5, vasoactive intestinal polypeptide receptor 1, carbonic anhydrase 14, and solute carrier family 15 member 3.
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Therapeutic Areas
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Trade Name
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EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Menkes kinky hair syndromeD007706111——2
Walker-warburg syndromeD058494Orphanet_899Q04.3—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G3511———2
Chronic renal insufficiencyD051436N18—1———1
Congenital heart defectsD006330HP_0001627Q24.9—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Irritable bowel syndromeD043183EFO_0000555K581————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHISTIDINE
INNhistidine
Description
L-histidine is the L-enantiomer of the amino acid histidine. It has a role as a nutraceutical, a micronutrient, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is a proteinogenic amino acid, a histidine and a L-alpha-amino acid. It is a conjugate base of a L-histidinium(1+). It is a conjugate acid of a L-histidinate(1-). It is an enantiomer of a D-histidine. It is a tautomer of a L-histidine zwitterion.
Classification
Small molecule
Drug classH2-receptor antagonists (cimetidine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N[C@@H](Cc1c[nH]cn1)C(=O)O
Identifiers
PDB1HTT
CAS-ID71-00-1
RxCUI5340
ChEMBL IDCHEMBL17962
ChEBI ID15971
PubChem CID6274
DrugBankDB00117
UNII ID4QD397987E (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADCYAP1R1
ADCYAP1R1
SLC15A4
SLC15A4
VIPR2
VIPR2
SCTR
SCTR
CA7
CA7
CA5A
CA5A
CA1
CA1
SLC38A5
SLC38A5
VIPR1
VIPR1
CA14
CA14
SLC15A3
SLC15A3
Organism
Homo sapiens
Gene name
ADCYAP1R1
Gene synonyms
NCBI Gene ID
117
Protein name
pituitary adenylate cyclase-activating polypeptide type I receptor
Protein synonyms
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, PACAP receptor 1, PACAP type I receptor, PACAP-R1, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop, pituitary adenylate cyclase-activating polypeptide type 1 receptor
Uniprot ID
Q17S10
Mouse ortholog
Adcyap1r1 (11517)
pituitary adenylate cyclase-activating polypeptide type I receptor (P70205)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 188,197 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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238 adverse events reported
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