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Homatropine
Equipin, Homapin, Hycodan (homatropine) is a small molecule pharmaceutical. Homatropine was first approved as Homapin-10 on 1982-01-01. It is used to treat inflammation in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Combinations
Hycodan (generic drugs available since 1983-03-03, discontinued: Hydropane, Tussigon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Homatropine methylbromide
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
HYCODANGenus LifesciencesN-005213 RX1988-07-26
2 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
hycodanNew Drug Application2021-12-29
hydrocodone bitartrate and homatropine methylbromideANDA2023-02-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
inflammationMP_0001845D007249—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03B: Belladonna and derivatives containing drugs, plain for functional gastrointestinal disorders
— A03BB: Belladonna alkaloids, semisynthetic, quaternary ammonium compounds for functional gastrointestinal disorders
— A03BB06: Homatropine methylbromide
— A03C: Antispasmodics in combination with psycholeptics
— A03CB: Belladonna and derivatives in combination with psycholeptics
— A03CB04: Homatropine methylbromide and psycholeptics
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01F: Mydriatics and cycloplegics
— S01FA: Anticholinergic mydriatics and cycloplegics
— S01FA05: Homatropine
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—25——6
AdenocarcinomaD000230——2——2
Bone neoplasmsD001859EFO_0003820D16——1——1
Precocious pubertyD011629E22.8——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHOMATROPINE
INNhomatropine methylbromide
Description
Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil).
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2
Identifiers
PDB—
CAS-ID87-00-3
RxCUI—
ChEMBL IDCHEMBL1618018
ChEBI ID5747
PubChem CID6321423
DrugBankDB00725
UNII ID68JRS2HC1C (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,454 documents
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Safety
Black-box Warning
Black-box warning for: Hycodan, Hydrocodone bitartrate and homatropine methylbromide
Adverse Events
Top Adverse Reactions
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892 adverse events reported
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