Boniva, Bondronat(ibandronic acid)
Bondronat, Boniva, Bonviva (ibandronic acid) is a small molecule pharmaceutical. Ibandronic acid was first approved as Bondronat on 1996-06-25. It is used to treat postmenopausal osteoporosis in the USA. It has been approved in Europe to treat acer, bone fractures, breast diseases, breast neoplasms, and calcium metabolism disorders amongst others. It is known to target farnesyl pyrophosphate synthase.
Download report
Favorite
Commercial
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| boniva | New Drug Application | 2021-11-16 |
| ibandronate sodium | ANDA | 2023-05-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| postmenopausal osteoporosis | EFO_0003854 | D015663 | — |
Agency Specific
FDA
EMA
No data
ATC Codes
M: Musculo-skeletal system drugs
— M05: Drugs for treatment of bone diseases
— M05B: Drugs affecting bone structure and mineralization
— M05BA: Bisphosphonate drugs affecting bone structure and mineralization
— M05BA06: Ibandronic acid
— M05BB: Bisphosphonates, combinations affecting bone structure and mineralization
— M05BB09: Ibandronic acid and colecalciferol
HCPCS
No data
Clinical
Clinical Trials
72 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | 2 | 6 | 16 | 3 | 27 | |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | 2 | 3 | 6 | 3 | 13 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | 2 | 4 | 2 | — | 8 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | — | 1 | 2 | — | 3 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 1 | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | — | — | 1 | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | 1 | — | 1 |
| Lung neoplasms | D008175 | C34.90 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 4 | — | 1 | 7 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 4 | — | — | 5 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 2 | — | — | 3 | |
| Neoplasms | D009369 | C80 | — | — | 3 | — | — | 3 | |
| Hypercalcemia | D006934 | E83.52 | — | — | 2 | — | — | 2 | |
| Osteonecrosis | D010020 | EFO_0004259 | M87 | — | — | 1 | — | — | 1 |
| Multiple myeloma | D009101 | C90.0 | — | — | 1 | — | — | 1 | |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | 1 | ||
| Prostatic neoplasms | D011471 | C61 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | IBANDRONIC ACID |
| INN | ibandronic acid |
| Description | Ibandronic acid is a bisphosphonate medication used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels). It is typically formulated as its sodium salt ibandronate sodium.
|
| Classification | Small molecule |
| Drug class | androgens |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O |
Identifiers
| PDB | 2F94 |
| CAS-ID | 114084-78-5 |
| RxCUI | 115264 |
| ChEMBL ID | CHEMBL997 |
| ChEBI ID | — |
| PubChem CID | 60852 |
| DrugBank | DB00710 |
| UNII ID | UMD7G2653W (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
FDPS
FDPS
Organism
Homo sapiens
Gene name
FDPS
Gene synonyms
FPS, KIAA1293
NCBI Gene ID
Protein name
farnesyl pyrophosphate synthase
Protein synonyms
(2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase, FPP synthase, FPP synthetase, Geranyltranstransferase
Uniprot ID
Mouse ortholog
Fdps (110196)
farnesyl pyrophosphate synthase (Q920E5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 3,707 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
387 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more