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Indusatumab vedotin
Indusatumab vedotin is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against guanylyl cyclase C.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AdenocarcinomaD00023011———2
Pancreatic neoplasmsD010190EFO_0003860C25—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gastrointestinal neoplasmsD005770C26.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameINDUSATUMAB VEDOTIN
INNindusatumab vedotin
Description
Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate that is under development for the treatment of pancreatic cancer and other gastrointestinal cancers. It consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE).
Classification
Antibody
Drug classsynthetic analogs of the dolastatin series; monoclonal antibodies
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID1514889-12-3
RxCUI—
ChEMBL IDCHEMBL4298045
ChEBI ID—
PubChem CID—
DrugBankDB12413
UNII ID3F0FR4W3H8 (ChemIDplus, GSRS)
Target
Agency Approved
GUCY2C
GUCY2C
Organism
Homo sapiens
Gene name
GUCY2C
Gene synonyms
GUC2C, STAR
NCBI Gene ID
2984
Protein name
guanylyl cyclase C
Protein synonyms
Heat-stable enterotoxin receptor, hSTAR, Intestinal guanylate cyclase, STA receptor
Uniprot ID
P25092
Mouse ortholog
Gucy2c (14917)
guanylyl cyclase C (Q8JZQ6)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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