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Picato(ingenol mebutate)
Picato (ingenol mebutate) is a small molecule pharmaceutical. Ingenol mebutate was first approved as Picato on 2012-01-23. It is used to treat actinic keratosis in the USA. It has been approved in Europe to treat actinic keratosis. The pharmaceutical is active against protein kinase C delta type. In addition, it is known to target protein kinase C epsilon type, protein kinase C beta type, protein kinase C alpha type, and protein kinase C gamma type.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ingenol mebutate
Tradename
Company
Number
Date
Products
PICATOLEO PharmaN-202833 DISCN2012-01-23
2 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
actinic keratosis—D055623L57.0
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Ingenol Mebutate, Picato, Leo Labs
97890782033-05-15U-2138
82782922027-07-06DP
83728272026-12-18DP
83728282026-12-18DP
83779192026-12-18DP
85361632026-12-18U-1440
87162712026-12-18U-1440
87353752026-12-18U-1440
98209592026-12-18DPU-1440
98334282026-12-18DP
98334292026-12-18DP
98616032026-12-18U-1440
ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06B: Chemotherapeutics for topical use
— D06BX: Other chemotherapeutics in atc
— D06BX02: Ingenol mebutate
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F203233111
Bipolar disorderD001714EFO_0000289F30.91—1215
Psychotic disordersD011618F20.81———2—2
Healthy volunteers/patients—1——1—2
Major depressive disorderD003865EFO_0003761F22———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Post-traumatic stress disordersD013313EFO_0001358F43.1—1———1
Parkinson diseaseD010300EFO_0002508G20—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatic insufficiencyD0485501————1
Therapeutic equivalencyD0138101————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameINGENOL MEBUTATE
INNingenol mebutate
Description
Ingenol mebutate is a tetracyclic diterpenoid ester obtained by formal condensation of the carboxy group of (2Z)-2-methylbut-2-enoic (angelic) acid with the 3-hydroxy group of ingenol. Used for the topical treatment of actinic keratosis. It has a role as an antineoplastic agent. It is a tetracyclic diterpenoid, a carboxylic ester and a cyclic terpene ketone. It is functionally related to an angelic acid and an ingenol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C/C=C(/C)C(=O)O[C@H]1C(C)=C[C@]23C(=O)[C@@H](C=C(CO)[C@@H](O)[C@]12O)[C@H]1[C@@H](C[C@H]3C)C1(C)C
Identifiers
PDB7KO6
CAS-ID75567-37-2
RxCUI1242806
ChEMBL IDCHEMBL1863513
ChEBI ID—
PubChem CID6918670
DrugBankDB05013
UNII ID7686S50JAH (ChemIDplus, GSRS)
Target
Agency Approved
PRKCD
PRKCD
Organism
Homo sapiens
Gene name
PRKCD
Gene synonyms
PKCD
NCBI Gene ID
5580
Protein name
protein kinase C delta type
Protein synonyms
nPKC-delta, protein kinase C delta VIII, Tyrosine-protein kinase PRKCD
Uniprot ID
Q86XJ6
Mouse ortholog
Prkcd (18753)
protein kinase C delta type (Q9Z333)
Alternate
PRKCE
PRKCE
PRKCB
PRKCB
PRKCA
PRKCA
PRKCG
PRKCG
Organism
Homo sapiens
Gene name
PRKCE
Gene synonyms
PKCE
NCBI Gene ID
5581
Protein name
protein kinase C epsilon type
Protein synonyms
nPKC-epsilon
Uniprot ID
Q9UE81
Mouse ortholog
Prkce (18754)
protein kinase C epsilon type (P16054)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 607 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,216 adverse events reported
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