Inositol
Inositol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target anoctamin-1, two pore channel protein 1, inositol polyphosphate-5-phosphatase A, inositol 1,4,5-trisphosphate receptor type 1, mucolipin-2, inositol 1,4,5-trisphosphate receptor type 2, inositol 1,4,5-trisphosphate receptor type 3, mucolipin-3, two pore channel protein 2, and mucolipin-1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11H: Other plain vitamin preparations in atc
— A11HA: Other plain vitamin preparations in atc
— A11HA07: Inositol
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AC: Nicotinic acid and derivatives, peripheral vasodilators
— C04AC03: Inositol nicotinate
HCPCS
No data
Clinical
Clinical Trials
85 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | 4 | 2 | 3 | 15 | 24 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | — | — | — | 1 | 9 | 10 |
| Infertility | D007246 | EFO_0000545 | — | 2 | 1 | 3 | 2 | 7 | |
| Insulin resistance | D007333 | EFO_0002614 | — | 2 | — | 1 | 2 | 5 | |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | 1 | — | 1 | 1 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | 1 | 2 |
| Ovulation induction | D010062 | — | — | — | 1 | — | 1 | ||
| Pediatric obesity | D063766 | — | — | — | 1 | — | 1 | ||
| Yin deficiency | D016710 | — | — | — | 1 | — | 1 | ||
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | 2 | 1 | — | — | 3 |
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | 1 | — | 1 | 2 |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | — | 1 | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 1 | — | — | 1 | 2 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | 1 | 2 |
| Hyperandrogenism | D017588 | — | 1 | — | — | 1 | 2 | ||
| Bronchopulmonary dysplasia | D001997 | P27.8 | — | 2 | — | — | — | 2 | |
| Anovulation | D000858 | — | 1 | — | — | — | 1 | ||
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | — | — | 1 |
| Humans | D006801 | STY/T016 | 1 | 1 | — | — | — | 1 | |
| Cryopreservation | D015925 | 1 | 1 | — | — | — | 1 | ||
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | 1 | — | — | — | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 1 | 1 | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hirsutism | D006628 | HP_0001007 | L68.0 | — | — | — | — | 2 | 2 |
| Menstruation disturbances | D008599 | HP_0400007 | N91.5 | — | — | — | — | 2 | 2 |
| Eunuchism | D005058 | EFO_0007266 | E29.1 | — | — | — | — | 1 | 1 |
| Depression | D003863 | F33.9 | — | — | — | — | 1 | 1 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Oligospermia | D009845 | N46.1 | — | — | — | — | 1 | 1 | |
| Asthenozoospermia | D053627 | — | — | — | — | 1 | 1 | ||
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | — | 1 | 1 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | INOSITOL |
| INN | inositol |
| Description | Myo-inositol is an inositol having myo- configuration. It has a role as a member of compatible osmolytes, a nutrient, an EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor, a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 87-89-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1222251 |
| ChEBI ID | 17268 |
| PubChem CID | 892 |
| DrugBank | DB03106 |
| UNII ID | 4L6452S749 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ANO1
ANO1
TPCN1
TPCN1
INPP5A
INPP5A
ITPR1
ITPR1
MCOLN2
MCOLN2
ITPR2
ITPR2
ITPR3
ITPR3
MCOLN3
MCOLN3
TPCN2
TPCN2
MCOLN1
MCOLN1
Organism
Homo sapiens
Gene name
ANO1
Gene synonyms
DOG1, ORAOV2, TAOS2, TMEM16A
NCBI Gene ID
Protein name
anoctamin-1
Protein synonyms
anoctamin 1, calcium activated chloride channel, Ca2+-activated Cl- channel, calcium activated chloride channel, Discovered on gastrointestinal stromal tumors protein 1, oral cancer overexpressed 2, Oral cancer overexpressed protein 2, Transmembrane protein 16A, transmembrane protein 16A (eight membrane-spanning domains), Tumor-amplified and overexpressed sequence 2
Uniprot ID
Mouse ortholog
Ano1 (101772)
anoctamin-1 (Q99JK1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 120,153 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16 adverse events reported
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