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Isoproterenol
Duo-medihaler, Isuprel, Medihaler-iso, Norisodrine (isoproterenol) is a small molecule pharmaceutical. Isoproterenol was first approved as Mucomyst w/ isoproterenol on 1982-01-01. It is used to treat adams-stokes syndrome, bradycardia, heart arrest, hemorrhagic shock, and low cardiac output amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor and beta-2 adrenergic receptor. In addition, it is known to target beta-3 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Isuprel (generic drugs available since 2017-08-02, discontinued: Aerolone, Medihaler-iso, Norisodrine, Norisodrine aerotrol, Vapo-iso)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetylcysteine
+
Isoproterenol hydrochloride
Tradename
Company
Number
Date
Products
MUCOMYST W/ ISOPROTERENOLMead Johnson NutritionN-017366 DISCN1982-01-01
1 products
Hide discontinued
Isoproterenol hydrochloride
Tradename
Company
Number
Date
Products
ISUPRELBausch Health CompaniesN-010515 RX1982-01-01
1 products, RLD, RS
Show 7 discontinued
Isoproterenol hydrochloride
+
Phenylephrine bitartrate
Tradename
Company
Number
Date
Products
DUO-MEDIHALER3MN-013296 DISCN1982-01-01
1 products
Hide discontinued
Isoproterenol sulfate
Tradename
Company
Number
Date
Products
MEDIHALER-ISO3MN-010375 DISCN1982-01-01
1 products
NORISODRINEAbbVieN-006905 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
isoproterenol hydrochlorideANDA2023-03-31
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
adams-stokes syndrome—D000219I45.9
bradycardiaHP_0001662D001919R00.1
heart arrestEFO_0009492D006323I46
hemorrhagic shock—D012771—
low cardiac output—D002303—
septic shock—D012772A48.3
torsades de pointesEFO_0005307D016171I47.21
ventricular fibrillationEFO_0004287D014693I49.01
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CA: Adrenergic and dopaminergic cardiac stimulants
— C01CA02: Isoprenaline
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AB: Non-selective beta-adrenoreceptor agonist inhalants
— R03AB02: Isoprenaline
— R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics
— R03AK02: Isoprenaline and other drugs for obstructive airway diseases
— R03C: Adrenergics for systemic use
— R03CB: Non-selective beta-adrenoreceptor agonists for systemic use
— R03CB01: Isoprenaline
— R03CB51: Isoprenaline, combinations
HCPCS
Code
Description
J7657
Isoproterenol hcl, inhalation solution, compounded product, administered through dme, concentrated form, per milligram
J7658
Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, concentrated form, per milligram
J7659
Isoproterenol hcl, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per milligram
J7660
Isoproterenol hcl, inhalation solution, compounded product, administered through dme, unit dose form, per milligram
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameISOPROTERENOL
INNisoprenaline
Description
Isoprenaline is a secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders. It has a role as a sympathomimetic agent, a beta-adrenergic agonist, a bronchodilator agent and a cardiotonic drug. It is a member of catechols, a secondary amino compound and a secondary alcohol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)NCC(O)c1ccc(O)c(O)c1
Identifiers
PDB—
CAS-ID7683-59-2
RxCUI6054
ChEMBL IDCHEMBL434
ChEBI ID64317
PubChem CID3779
DrugBankDB01064
UNII IDL628TT009W (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
153
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
P08588
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
ADRB3
ADRB3
Organism
Homo sapiens
Gene name
ADRB3
Gene synonyms
ADRB3R, B3AR
NCBI Gene ID
155
Protein name
beta-3 adrenergic receptor
Protein synonyms
adrenergic, beta-3-, receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor
Uniprot ID
Q4JFT4
Mouse ortholog
Adrb3 (11556)
beta-3 adrenergic receptor (Q9QZ98)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 37,711 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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21 adverse events reported
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