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Ketanserin
Ketanserin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, alpha-1B adrenergic receptor, synaptic vesicular amine transporter, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 5A, alpha-1D adrenergic receptor, D(1B) dopamine receptor, alpha-1A adrenergic receptor, chromaffin granule amine transporter, D(1A) dopamine receptor, and 5-hydroxytryptamine receptor 1A.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02K: Other antihypertensives in atc
— C02KD: Serotonin antagonists, antihypertensives
— C02KD01: Ketanserin
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Critical illnessD016638———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute kidney injuryD058186HP_0001919N17——1——1
SepsisD018805A41.9——1——1
Septic shockD012772A48.3——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetic footD017719EFO_100145911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2———13
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameKETANSERIN
INNketanserin
Description
Ketanserin is a member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group. It has a role as an alpha-adrenergic antagonist, a serotonergic antagonist, an antihypertensive agent, a cardiovascular drug and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a member of quinazolines, a member of piperidines, an organofluorine compound and an aromatic ketone. It is a conjugate base of a ketanserin(1+).
Classification
Small molecule
Drug classserotonin 5-HT2 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(c1ccc(F)cc1)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Identifiers
PDB—
CAS-ID74050-98-9
RxCUI6131
ChEMBL IDCHEMBL51
ChEBI ID6123
PubChem CID3822
DrugBankDB12465
UNII ID97F9DE4CT4 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR2A
HTR2A
HTR7
HTR7
HTR2B
HTR2B
HTR2C
HTR2C
ADRA1B
ADRA1B
SLC18A2
SLC18A2
HTR1D
HTR1D
HTR1B
HTR1B
HTR5A
HTR5A
ADRA1D
ADRA1D
DRD5
DRD5
ADRA1A
ADRA1A
SLC18A1
SLC18A1
DRD1
DRD1
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR2A
Gene synonyms
HTR2
NCBI Gene ID
3356
Protein name
5-hydroxytryptamine receptor 2A
Protein synonyms
5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor, Serotonin receptor 2A
Uniprot ID
Q5T8C0
Mouse ortholog
Htr2a (15558)
5-hydroxytryptamine receptor 2A (P35363)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,302 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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12 adverse events reported
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