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Lanabecestat
Lanabecestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against beta-secretase 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
19 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F03113——4
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—10————10
Renal insufficiencyD051437HP_0000083N191————1
Hepatic insufficiencyD0485501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLANABECESTAT
INNlanabecestat
Description
Lanabecestat (formerly known as AZD3293 or LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. A BACE inhibitor in theory would prevent the buildup of beta-amyloid and may help slow or stop the progression of Alzheimer's disease.
Classification
Small molecule
Drug classcannabinol derivatives; enzyme inhibitors: beta secretase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1
Identifiers
PDB—
CAS-ID1383982-64-6
RxCUI—
ChEMBL IDCHEMBL3989948
ChEBI ID—
PubChem CID57404290
DrugBank—
UNII IDX8SPJ492VF (ChemIDplus, GSRS)
Target
Agency Approved
BACE1
BACE1
Organism
Homo sapiens
Gene name
BACE1
Gene synonyms
BACE, KIAA1149
NCBI Gene ID
23621
Protein name
beta-secretase 1
Protein synonyms
APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2
Uniprot ID
P56817
Mouse ortholog
Bace1 (23821)
beta-secretase 1 (P56818)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 165 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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