Lenrispodun
Lenrispodun is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B and cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | 1 | 1 | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LENRISPODUN |
| INN | lenrispodun |
| Description | Lenrispodun is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B and cAMP-specific 3',5'-cyclic phosphodiesterase 4A. |
| Classification | Small molecule |
| Drug class | phosphodiesterase type 1 (PDE1) ihibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN1C(=O)c2c(nn(Cc3ccc(-c4cccc(F)n4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 1160521-50-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3769414 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3GBO34D1BE (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE1B
PDE1B
PDE4A
PDE4A
Organism
Homo sapiens
Gene name
PDE1B
Gene synonyms
PDES1B
NCBI Gene ID
Protein name
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Protein synonyms
63 kDa Cam-PDE, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase, calmodulin-stimulated phosphodiesterase PDE1B1, cam-PDE 1B, epididymis secretory sperm binding protein Li 79p, phosphodiesterase 1B, calmodulin-dependent, presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
Uniprot ID
Mouse ortholog
Pde1b (18574)
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Q01065)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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