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Lerociclib
Lerociclib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cyclin-dependent kinase 4 and cyclin-dependent kinase 6.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5012———2
Ductal carcinoma breastD01827011———1
Non-small-cell lung carcinomaD00228911———1
Lung neoplasmsD008175C34.9011———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLEROCICLIB
INNlerociclib
Description
Lerociclib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cyclin-dependent kinase 4 and cyclin-dependent kinase 6.
Classification
Small molecule
Drug classcyclin dependent kinase inhibitors (formerly-cidib)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1
Identifiers
PDB—
CAS-ID1628256-23-4
RxCUI—
ChEMBL IDCHEMBL3904602
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDWBH8AY6ENB (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CDK4
CDK4
CDK6
CDK6
Organism
Homo sapiens
Gene name
CDK4
Gene synonyms
NCBI Gene ID
1019
Protein name
cyclin-dependent kinase 4
Protein synonyms
Cell division protein kinase 4, PSK-J3
Uniprot ID
Q6FG61
Mouse ortholog
Cdk4 (12567)
cyclin-dependent kinase 4 (P30285)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 30 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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57 adverse events reported
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