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Zurampic(lesinurad)
Duzallo, Zurampic (lesinurad) is a small molecule pharmaceutical. Lesinurad was first approved as Zurampic on 2015-12-22. It is used to treat hyperuricemia in the USA. It has been approved in Europe to treat gout and hyperuricemia. It is known to target solute carrier family 22 member 12.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol
+
Lesinurad
Tradename
Company
Number
Date
Products
DUZALLOIronwood PharmaceuticalsN-209203 DISCN2017-08-18
2 products, RLD
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Lesinurad
Tradename
Company
Number
Date
Products
ZURAMPICIronwood PharmaceuticalsN-207988 DISCN2015-12-22
1 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hyperuricemia—D033461—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Allopurinol / Lesinurad, Duzallo, Ironwood Pharms Inc
85464362032-02-29DS, DP
99562052031-12-28U-2104, U-2311
92161792031-08-01U-1806, U-2104
83577132029-12-22DPU-1801, U-1802, U-1803, U-2104
80844832029-08-17U-1801, U-2104
85464372029-04-29U-1803, U-2104
82833692028-11-26U-1802, U-1804, U-2104
101830122028-11-26U-2104, U-2311
80036812025-08-25DP
ATC Codes
M: Musculo-skeletal system drugs
— M04: Antigout preparations
— M04A: Antigout preparations
— M04AB: Preparations increasing uric acid excretion
— M04AB05: Lesinurad
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ocular hypertensionD009798EFO_1001069H40.0—13116
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Open-angle glaucomaD005902EFO_0004190H40.1—12—14
GlaucomaD005901EFO_0000516H40——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intraocular pressureD00742911———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLESINURAD
INNlesinurad
Description
Lesinurad is a member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout. It has a role as a uricosuric drug. It is a member of triazoles, a member of naphthalenes, a member of cyclopropanes, an organobromine compound, an aryl sulfide and a monocarboxylic acid.
Classification
Small molecule
Drug classurate transporter inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12
Identifiers
PDB—
CAS-ID878672-00-5
RxCUI1731031
ChEMBL IDCHEMBL2105720
ChEBI ID—
PubChem CID53465279
DrugBankDB11560
UNII ID09ERP08I3W (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC22A12
SLC22A12
Organism
Homo sapiens
Gene name
SLC22A12
Gene synonyms
OATL4, URAT1
NCBI Gene ID
116085
Protein name
solute carrier family 22 member 12
Protein synonyms
Organic anion transporter 4-like protein, Renal-specific transporter, RST, solute carrier family 22 (organic anion/cation transporter), member 12, solute carrier family 22 (organic anion/urate transporter), member 12, URAT1, Urate anion exchanger 1, urate anion transporter 1, urate transporter 1, Urate:anion antiporter SLC22A12
Uniprot ID
Q96S37
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
Zurampic - Ironwood Pharmaceuticals
$
€
£
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Lesinurad - Ironwood Pharmaceuticals
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 380 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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259 adverse events reported
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