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Lesogaberan
Lesogaberan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against gamma-aminobutyric acid type B receptor subunit 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gastroesophageal refluxD005764EFO_0003948K2125———7
Mitral valve insufficiencyD008944HP_0001653—2———2
HeartburnD006356R12—2———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal eliminationD0656671————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLESOGABERAN
INNlesogaberan
Description
Lesogaberan (AZD-3355) was an experimental drug candidate developed by AstraZeneca for the treatment of gastroesophageal reflux disease (GERD). As a GABAB receptor agonist, it has the same mechanism of action as baclofen, but is anticipated to have fewer of the central nervous system side effects that limit the clinical use of baclofen for the treatment of GERD.
Classification
Small molecule
Drug classgabamimetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NC[C@@H](F)C[PH](=O)O
Identifiers
PDB—
CAS-ID344413-67-8
RxCUI—
ChEMBL IDCHEMBL448343
ChEBI ID—
PubChem CID16686147
DrugBankDB11920
UNII ID4D6Q6HGC7Z (ChemIDplus, GSRS)
Target
Agency Approved
GABBR1
GABBR1
Organism
Homo sapiens
Gene name
GABBR1
Gene synonyms
GPRC3A
NCBI Gene ID
2550
Protein name
gamma-aminobutyric acid type B receptor subunit 1
Protein synonyms
GABA-B receptor, R1 subunit, gamma-aminobutyric acid (GABA) B receptor, 1, seven transmembrane helix receptor
Uniprot ID
Q9UBS5
Mouse ortholog
Gabbr1 (54393)
gamma-aminobutyric acid type B receptor subunit 1 (Q9WV18)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 80 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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80 adverse events reported
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