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Leucovorin
Wellcovorin (leucovorin) is a small molecule pharmaceutical. Leucovorin was first approved as Leucovorin calcium on 1982-01-01. It is used to treat folic acid deficiency and megaloblastic anemia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hemic and lymphatic diseasesD006425
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Leucovorin calcium
Tradename
Company
Number
Date
Products
WELLCOVORINGSKN-018342 DISCN1983-07-08
2 products, RLD
LEUCOVORIN CALCIUMHospiraN-008107 DISCN1982-01-01
5 products, RLD
LEUCOVORIN CALCIUMXanodyne PharmaceuticalsN-018459 DISCN1986-01-30
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
leucovorin calciumANDA2023-02-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
folic acid deficiencyEFO_0001070D005494E53.8
megaloblastic anemia—D000749D53.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AF: Detoxifying agents for antineoplastic treatment
— V03AF03: Calcium folinate
HCPCS
Code
Description
J0640
Injection, leucovorin calcium, per 50 mg
J0641
Injection, levoleucovorin, not otherwise specified, 0.5 mg
J0642
Injection, levoleucovorin (khapzory), 0.5 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLEUCOVORIN
INNcalcium folinate
Description
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2C=O
Identifiers
PDB—
CAS-ID58-05-9
RxCUI—
ChEMBL IDCHEMBL1679
ChEBI ID15640
PubChem CID6006
DrugBankDB03256
UNII IDRPR1R4C0P4 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,554 adverse events reported
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