Leucovorin calcium
Wellcovorin (leucovorin calcium) is a small molecule pharmaceutical. Leucovorin calcium was first approved as Leucovorin calcium on 1982-01-01. It is used to treat folic acid deficiency and megaloblastic anemia in the USA.
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FDA
EMA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| leucovorin calcium | ANDA | 2023-02-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| folic acid deficiency | EFO_0001070 | D005494 | E53.8 |
| megaloblastic anemia | — | D000749 | D53.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0640 | Injection, leucovorin calcium, per 50 mg |
Clinical
Clinical Trials
1390 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | 62 | 210 | 116 | 3 | 10 | 367 | ||
| Neoplasms | D009369 | C80 | 56 | 30 | 12 | 2 | — | 94 | |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 19 | 60 | 15 | 2 | 5 | 93 |
| Adenocarcinoma | D000230 | 14 | 35 | 16 | 1 | 1 | 58 | ||
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 6 | 17 | 11 | 6 | — | 38 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | 3 | 3 | 2 | 15 | 24 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | 3 | 1 | 5 | 10 | 18 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 1 | 3 | 2 | 8 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 4 | 3 | 8 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | 2 | 5 | 7 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 44 | 65 | 15 | — | 2 | 106 |
| Rectal neoplasms | D012004 | 18 | 40 | 12 | — | 1 | 66 | ||
| Colonic neoplasms | D003110 | C18 | 13 | 23 | 16 | — | 2 | 48 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 11 | 23 | 16 | — | 2 | 44 | |
| Lymphoma | D008223 | C85.9 | 7 | 24 | 10 | — | 4 | 44 | |
| Esophageal neoplasms | D004938 | C15 | 10 | 30 | 5 | — | 1 | 41 | |
| Leukemia | D007938 | C95 | 3 | 23 | 11 | — | 2 | 39 | |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 7 | 13 | 6 | — | 3 | 27 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 5 | 3 | 8 | — | 8 | 24 |
| Pancreatic ductal carcinoma | D021441 | 9 | 10 | 2 | — | — | 19 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | D002292 | 7 | 6 | — | — | — | 12 | ||
| Myelodysplastic syndromes | D009190 | D46 | 7 | 4 | — | — | — | 10 | |
| Sarcoma | D012509 | 3 | 5 | — | — | — | 8 | ||
| Osteosarcoma | D012516 | 3 | 4 | — | — | 2 | 8 | ||
| Myeloid leukemia acute | D015470 | C92.0 | 7 | 1 | — | — | — | 7 | |
| Fallopian tube neoplasms | D005185 | 7 | 1 | — | — | — | 7 | ||
| Triple negative breast neoplasms | D064726 | 4 | 4 | — | — | — | 6 | ||
| Melanoma | D008545 | 5 | 2 | — | — | — | 6 | ||
| Acinar cell carcinoma | D018267 | 4 | 2 | — | — | — | 6 | ||
| Peritoneal neoplasms | D010534 | 3 | 3 | — | — | 1 | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 5 | — | — | — | 8 | 13 | ||
| Pharmacokinetics | D010599 | 5 | — | — | — | — | 5 | ||
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 3 | — | — | — | — | 3 |
| Cognitive dysfunction | D060825 | G31.84 | 1 | — | — | — | 2 | 3 | |
| Ovarian epithelial carcinoma | D000077216 | 2 | — | — | — | — | 2 | ||
| T-cell lymphoma cutaneous | D016410 | C84.A | 2 | — | — | — | — | 2 | |
| Drug interactions | D004347 | 2 | — | — | — | — | 2 | ||
| Therapeutic equivalency | D013810 | 2 | — | — | — | — | 2 | ||
| Hematologic neoplasms | D019337 | 1 | — | — | — | — | 1 | ||
| Primary myelofibrosis | D055728 | D47.4 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | — | 2 | 2 |
| Gyrate atrophy | D015799 | — | — | — | — | 2 | 2 | ||
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | — | — | 2 | 2 |
| Mortality | D009026 | EFO_0004352 | — | — | — | — | 2 | 2 | |
| Spinal dysraphism | D016135 | EFO_1001210 | Q05 | — | — | — | — | 2 | 2 |
| Parturition | D036801 | — | — | — | — | 1 | 1 | ||
| Live birth | D050498 | — | — | — | — | 1 | 1 | ||
| Invasive hydatidiform mole | D002820 | D39.2 | — | — | — | — | 1 | 1 | |
| Juvenile arthritis | D001171 | EFO_0002609 | M08 | — | — | — | — | 1 | 1 |
| Delirium | D003693 | R41.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LEUCOVORIN CALCIUM |
| INN | calcium folinate |
| Description | Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)N2C=O.[Ca+2] |
Identifiers
| PDB | — |
| CAS-ID | 1492-18-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201138 |
| ChEBI ID | — |
| PubChem CID | 6006 |
| DrugBank | DB00650 |
| UNII ID | RPR1R4C0P4 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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29,028 adverse events reported
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