Levocarnitine
Carnitor (levocarnitine) is a small molecule pharmaceutical. Levocarnitine was first approved as Carnitor on 1985-12-27. It is used to treat deficiency diseases in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Carnitor, Carnitor sf (generic drugs available since 2001-03-29)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levocarnitine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CARNITOR | Leadiant Biosciences | N-018948 RX | 1985-12-27 | 1 products, RLD, RS |
| CARNITOR SF | Leadiant Biosciences | N-019257 RX | 2007-03-28 | 1 products, RLD |
| CARNITOR | Leadiant Biosciences | N-019257 RX | 1986-04-10 | 1 products, RLD, RS |
| CARNITOR | Leadiant Biosciences | N-020182 RX | 1992-12-16 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| carnitor sf | New Drug Application | 2022-12-08 |
| levocarnitine | ANDA | 2023-01-06 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| deficiency diseases | EFO_1001067 | D003677 | E63 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1955 | Injection, levocarnitine, per 1 gm |
Clinical
Clinical Trials
302 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | C61 | 20 | 72 | 41 | 11 | 15 | 147 | |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 8 | 3 | 3 | 3 | 18 |
| Precocious puberty | D011629 | E22.8 | 1 | — | 6 | 7 | 2 | 16 | |
| Infertility | D007246 | EFO_0000545 | 1 | — | 2 | 5 | 2 | 10 | |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | 2 | 3 | 3 | 1 | 9 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | 1 | — | 3 | 1 | 6 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | 2 | 1 | 3 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | — | 2 | — | 2 | ||
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | 1 | 1 | 2 |
| Amenorrhea | D000568 | N91.2 | — | 1 | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 11 | 8 | — | 3 | 22 |
| Adenocarcinoma | D000230 | 2 | 15 | 7 | — | — | 21 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | — | 1 | — | 2 | 5 |
| Neoplasms | D009369 | C80 | — | 2 | 1 | — | — | 3 | |
| Castration-resistant prostatic neoplasms | D064129 | — | 1 | 2 | — | — | 2 | ||
| Pedophilia | D010378 | F65.4 | — | 1 | 2 | — | — | 2 | |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | — | 1 | — | — | 1 |
| Male breast neoplasms | D018567 | — | — | 1 | — | — | 1 | ||
| Dyspareunia | D004414 | HP_0030016 | N94.1 | — | — | 1 | — | — | 1 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | 1 | — | — | 1 |
Show 9 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | C85.9 | — | 3 | — | — | — | 3 | |
| Multiple myeloma | D009101 | C90.0 | — | 3 | — | — | — | 3 | |
| Healthy volunteers/patients | — | 3 | 1 | — | — | — | 3 | ||
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 3 | — | — | — | 3 |
| Hypogonadism | D007006 | E23.0 | — | 1 | — | — | 2 | 3 | |
| Myeloid leukemia acute | D015470 | C92.0 | — | 2 | — | — | — | 2 | |
| Hodgkin disease | D006689 | C81 | — | 2 | — | — | — | 2 | |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | — | 1 | — | — | 1 | 2 |
| Myelodysplastic syndromes | D009190 | D46 | — | 2 | — | — | — | 2 | |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | — | — | 1 | 2 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 1 | 2 |
| Hiv | D006678 | O98.7 | 1 | — | — | — | — | 1 | |
| Transgenes | D019076 | 1 | — | — | — | — | 1 | ||
| Delayed puberty | D011628 | HP_0000823 | E30.0 | 1 | — | — | — | — | 1 |
| Menstruation disturbances | D008599 | HP_0400007 | N91.5 | 1 | — | — | — | — | 1 |
| Premenstrual syndrome | D011293 | N94.3 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Embryo implantation | D010064 | — | — | — | — | 1 | 1 | ||
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
| Coronary disease | D003327 | — | — | — | — | 1 | 1 | ||
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | — | — | — | — | 1 | 1 |
| Hemangioma | D006391 | D18.0 | — | — | — | — | 1 | 1 | |
| Pregnancy rate | D018873 | — | — | — | — | 1 | 1 | ||
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | — | — | — | 1 | 1 | |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LEVOCARNITINE |
| INN | levocarnitine |
| Description | Carnitine is an amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4. It has a role as a human metabolite and a mouse metabolite. It is functionally related to a butyrate. It is a conjugate base of a carnitinium. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[N+](C)(C)C[C@H](O)CC(=O)[O-] |
Identifiers
| PDB | — |
| CAS-ID | 406-76-8 |
| RxCUI | 2106 |
| ChEMBL ID | CHEMBL1149 |
| ChEBI ID | 16347 |
| PubChem CID | 288 |
| DrugBank | DB00583 |
| UNII ID | 0G389FZZ9M (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 872 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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50,275 adverse events reported
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