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Levorphanol
Levo-dromoran (levorphanol) is a small molecule pharmaceutical. Levorphanol was first approved as Levo-dromoran on 1991-12-19. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target glutamate receptor ionotropic, NMDA 2C.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levorphanol tartrate
Tradename
Company
Number
Date
Products
LEVO-DROMORANBausch Health CompaniesN-008719 DISCN1991-12-19
1 products
LEVO-DROMORANBausch Health CompaniesN-008720 DISCN1991-12-19
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
levorphanol tartrateANDA2022-11-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code
Description
J1960
Injection, levorphanol tartrate, up to 2 mg
Clinical
Clinical Trials
59 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52——1528
AnesthesiaD000758———224
Hip osteoarthritisD015207EFO_1000786M16—112—3
Postoperative painD010149G89.18———213
PulpitisD011671EFO_1001139K04.0———123
Local anesthesiaD000772—111—3
Knee osteoarthritisD020370EFO_0004616M17—111—2
Nerve blockD009407———112
Spinal anesthesiaD000775———2—2
HypertensionD006973EFO_0000537I10———2—2
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
RuptureD012421——1—12
Wounds and injuriesD014947T14.8——1——1
EmergenciesD004630——1——1
AnalgesiaD000698——1——1
Vaginal dischargeD019522——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.511———1
Intervertebral disc degenerationD055959HP_000841911———1
Ischemic strokeD000083242—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Compartment syndromesD003161T79.A01————1
Healthy volunteers/patients—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I95————11
Anterior cruciate ligament injuriesD000070598————11
Orthodontic anchorage proceduresD052280————11
BursitisD002062EFO_1000941M71.9————11
EdemaD004487R60.9————11
TrismusD014313————11
Chronic renal insufficiencyD051436N18————11
Neuromuscular blockadeD019148————11
VibrationD014732————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLEVORPHANOL
INNlevorphanol
Description
Levorphanol is a morphinane alkaloid.
Classification
Small molecule
Drug classnarcotic antagonists/agonists (morphinan derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13
Identifiers
PDB—
CAS-ID77-07-6
RxCUI6378
ChEMBL IDCHEMBL592
ChEBI ID6444
PubChem CID5359272
DrugBankDB00854
UNII ID27618J1N2X (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
GRIN2C
GRIN2C
Organism
Homo sapiens
Gene name
GRIN2C
Gene synonyms
NMDAR2C
NCBI Gene ID
2905
Protein name
glutamate receptor ionotropic, NMDA 2C
Protein synonyms
GluN2C(alt_5'UTR_77nt), GluN2C(alt_5'UTR_87nt), GluN2C(del_e2), GluN2C-b alternative isoform, Glutamate [NMDA] receptor subunit epsilon-3, glutamate receptor, ionotropic, N-methyl D-aspartate 2C, N-methyl D-aspartate receptor subtype 2C, N-methyl-D-aspartate receptor subunit 2C, NMDAR2C, NR2C, putative NMDtranscript(altAcc_e11), putative NMDtranscript(altDon_e4), putative NMDtranscript(del_e4)
Uniprot ID
Q14957
Mouse ortholog
Grin2c (14813)
glutamate receptor ionotropic, NMDA 2C (Q01098)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 863 documents
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Safety
Black-box Warning
Black-box warning for: Levorphanol tartrate
Adverse Events
Top Adverse Reactions
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266 adverse events reported
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