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Lifirafenib
Lifirafenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serine/threonine-protein kinase A-Raf, epidermal growth factor receptor, and serine/threonine-protein kinase B-raf.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C803————3
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLIFIRAFENIB
INNlifirafenib
Description
Lifirafenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serine/threonine-protein kinase A-Raf, epidermal growth factor receptor, and serine/threonine-protein kinase B-raf.
Classification
Small molecule
Drug classrapidly accelerated fibrosarcoma (RAF) kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3[C@H](O4)[C@H]3c3nc4cc(C(F)(F)F)ccc4[nH]3)ccnc2N1
Identifiers
PDB—
CAS-ID1446090-77-2
RxCUI—
ChEMBL IDCHEMBL4209157
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID8762XZS5ZF (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ARAF
ARAF
EGFR
EGFR
BRAF
BRAF
Organism
Homo sapiens
Gene name
ARAF
Gene synonyms
ARAF1, PKS, PKS2
NCBI Gene ID
369
Protein name
serine/threonine-protein kinase A-Raf
Protein synonyms
A-Raf proto-oncogene serine/threonine-protein kinase, Oncogene ARAF1, Proto-oncogene A-Raf, Proto-oncogene A-Raf-1, Proto-oncogene Pks, Ras-binding protein DA-Raf, v-raf murine sarcoma 3611 viral oncogene homolog 1, v-raf murine sarcoma 3611 viral oncogene-like protein
Uniprot ID
P10398
Mouse ortholog
Araf (11836)
serine/threonine-protein kinase A-Raf (P04627)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 53 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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