Liothyronine
Cytomel, Triostat (liothyronine) is a small molecule pharmaceutical. Liothyronine was first approved as Cytomel on 1982-01-01. It is used to treat autoimmune thyroiditis, goiter, myxedema, thyroid neoplasms, and thyrotoxicosis in the USA. The pharmaceutical is active against thyroid hormone receptor alpha and thyroid hormone receptor beta.
Download report
Favorite
Commercial
Trade Name
FDA
EMA
Cytomel, Triostat (generic drugs available since 2005-08-17)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cytomel | New Drug Application | 2019-07-24 |
| np thyroid 90 | unapproved drug other | 2023-06-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| autoimmune thyroiditis | EFO_0006812 | D013967 | E06.3 |
| goiter | EFO_0004283 | D006042 | E04.9 |
| myxedema | EFO_1001055 | D009230 | E03.9 |
| thyroid neoplasms | EFO_0003841 | D013964 | — |
| thyrotoxicosis | — | D013971 | E05 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | LIOTHYRONINE |
| INN | liothyronine |
| Description | 3,3',5-triiodo-L-thyronine is an iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. It has a role as a thyroid hormone, a human metabolite and a mouse metabolite. It is an iodophenol, a 2-halophenol and an iodothyronine. It is a conjugate acid of a 3,3',5-triiodo-L-thyroninate. It is a tautomer of a 3,3',5-triiodo-L-thyronine zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O |
Identifiers
| PDB | 3UVV |
| CAS-ID | 6893-02-3 |
| RxCUI | 10814 |
| ChEMBL ID | CHEMBL1544 |
| ChEBI ID | 18258 |
| PubChem CID | 5920 |
| DrugBank | DB00279 |
| UNII ID | 06LU7C9H1V (ChemIDplus, GSRS) |
Target
Agency Approved
THRA
THRA
THRB
THRB
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 1,042 documents
View more details
Safety
Black-box Warning
Black-box warning for: Cytomel, Np thyroid 90
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
261 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more