Lirentelimab
Lirentelimab is an antibody pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Duodenitis | D004382 | K29.8 | — | 1 | 4 | — | — | 5 | |
| Gastritis | D005756 | EFO_0000217 | K29.7 | — | 2 | 3 | — | — | 5 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | 2 | 1 | — | — | 3 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic urticaria | D000080223 | L50.8 | — | 2 | — | — | — | 2 | |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 1 | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LIRENTELIMAB |
| INN | lirentelimab |
| Description | Lirentelimab (sold under the brand name AK002) is a humanized nonfucosylated monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). In a randomized clinical trial, lirentelimab was found to improve eosinophil counts and symptoms in individuals with eosinophilic gastritis and duodenitis. Adverse reactions include infusion reactions, which are mild to moderate and typically occur following the first infusion.
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| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | 7QUH |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297878 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | SWS48LJU3T (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 75 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
0 adverse events reported
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