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Lisuride
Lisuride is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 1B, D(4) dopamine receptor, D(1A) dopamine receptor, alpha-2C adrenergic receptor, D(2) dopamine receptor, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 2C, alpha-1A adrenergic receptor, alpha-2A adrenergic receptor, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1D, D(3) dopamine receptor, 5-hydroxytryptamine receptor 6, and 5-hydroxytryptamine receptor 2B.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02C: Other gynecologicals in atc
— G02CB: Prolactine inhibitors
— G02CB02: Lisuride
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CA: Ergot alkaloids, antimigraine
— N02CA07: Lisuride
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20—11——2
Restless legs syndromeD012148EFO_0004270G25.81——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F141————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLISURIDE
INNlisuride
Description
Lisuride is a monocarboxylic acid amide. It has a role as an antiparkinson drug, a serotonergic agonist, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an ergoline.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1
Identifiers
PDB7WC7
CAS-ID18016-80-3
RxCUI6446
ChEMBL IDCHEMBL157138
ChEBI ID51164
PubChem CID28864
DrugBankDB00589
UNII IDE0QN3D755O (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR1B
HTR1B
DRD4
DRD4
DRD1
DRD1
ADRA2C
ADRA2C
DRD2
DRD2
DRD5
DRD5
HTR2C
HTR2C
ADRA1A
ADRA1A
ADRA2A
ADRA2A
ADRA2B
ADRA2B
HTR1A
HTR1A
HTR2A
HTR2A
HTR1D
HTR1D
DRD3
DRD3
HTR6
HTR6
HTR2B
HTR2B
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
3351
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Q4VAY7
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 817 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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