Lorazepam
Ativan, Loreev (lorazepam) is a small molecule pharmaceutical. Lorazepam was first approved as Ativan on 1982-01-01. It is used to treat anxiety disorders, catatonia, depressive disorder, partial epilepsies, and psychotic disorders amongst others in the USA. It is known to target ovarian cancer G-protein coupled receptor 1 and alpha-1B adrenergic receptor.
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Commercial
Trade Name
FDA
EMA
Ativan, Loreev (generic drugs available since 1987-04-21, discontinued: Loraz)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anxiety disorders | EFO_0006788 | D001008 | F41.1 |
| catatonia | — | D002389 | F06.1 |
| depressive disorder | EFO_1002014 | D003866 | F32.A |
| partial epilepsies | EFO_0004263 | D004828 | — |
| psychotic disorders | — | D011618 | F20.81 |
| sleep initiation and maintenance disorders | — | D007319 | F51.01 |
| status epilepticus | EFO_0008526 | D013226 | G41 |
| substance withdrawal syndrome | EFO_0005800 | D013375 | — |
| vomiting | HP_0002013 | D014839 | R11.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Lorazepam, Loreev Xr, Almatica | |||
| 8999393 | 2034-01-08 | DP | U-3210 |
HCPCS
Code | Description |
|---|---|
| J2060 | Injection, lorazepam, 2 mg |
Clinical
Clinical Trials
94 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | 10 | 23 | 11 | — | 3 | 39 | |
| Central nervous system neoplasms | D016543 | 2 | 7 | 11 | — | 2 | 21 | ||
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 3 | 4 | 4 | — | — | 10 |
| Medulloblastoma | D008527 | 2 | 5 | 2 | — | — | 8 | ||
| Astrocytoma | D001254 | EFO_0000271 | — | 3 | 3 | — | — | 5 | |
| Glioma | D005910 | EFO_0000520 | 2 | 1 | 1 | — | — | 4 | |
| Gliosarcoma | D018316 | 1 | 1 | 1 | — | — | 3 | ||
| Leukemia | D007938 | C95 | — | 1 | 1 | — | — | 2 | |
| Myeloid leukemia acute | D015470 | C92.0 | — | — | 2 | — | — | 2 | |
| Disability evaluation | D004185 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | C85.9 | — | 5 | — | — | 1 | 6 | |
| Neoplasms | D009369 | C80 | 1 | 2 | — | — | — | 2 | |
| Lung neoplasms | D008175 | C34.90 | — | 2 | — | — | — | 2 | |
| Neoplasm metastasis | D009362 | EFO_0009708 | 1 | 1 | — | — | — | 2 | |
| Melanoma | D008545 | 1 | 1 | — | — | — | 2 | ||
| Graft vs host disease | D006086 | D89.81 | — | 1 | — | — | — | 1 | |
| Colorectal neoplasms | D015179 | — | 1 | — | — | — | 1 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | 1 | — | — | — | 1 |
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Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LORAZEPAM |
| INN | lorazepam |
| Description | Lorazepam is a benzodiazepine. |
| Classification | Small molecule |
| Drug class | antianxiety agents (diazepam type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O |
Identifiers
| PDB | — |
| CAS-ID | 846-49-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL580 |
| ChEBI ID | — |
| PubChem CID | 3958 |
| DrugBank | DB00186 |
| UNII ID | O26FZP769L (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GPR68
GPR68
ADRA1B
ADRA1B
Organism
Homo sapiens
Gene name
GPR68
Gene synonyms
OGR1
NCBI Gene ID
Protein name
ovarian cancer G-protein coupled receptor 1
Protein synonyms
G-protein coupled receptor 68, GPR12A, ovarian cancer G protein-coupled receptor, 1, Sphingosylphosphorylcholine receptor
Uniprot ID
Mouse ortholog
Gpr68 (238377)
ovarian cancer G-protein coupled receptor 1 (Q8BFQ3)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 835 documents
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Safety
Black-box Warning
Black-box warning for: Ativan, Lorazepam, Loreev xr
Adverse Events
Top Adverse Reactions
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1,294 adverse events reported
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