Losartan
Cozaar, Hyzaar (losartan) is a small molecule pharmaceutical. Losartan was first approved as Cozaar on 1995-04-14. It is used to treat diabetic nephropathies, heart failure, hypertension, left ventricular dysfunction, and left ventricular hypertrophy in the USA. The pharmaceutical is active against type-1 angiotensin II receptor. In addition, it is known to target cytochrome P450 2C9.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| cardiovascular diseases | D002318 |
| endocrine system diseases | D004700 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Cozaar (generic drugs available since 2010-01-06)
CombinationsHyzaar (generic drugs available since 2010-01-06)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cozaar | New Drug Application | 2021-10-15 |
| hyzaar | New Drug Application | 2021-06-01 |
| losartan potassium | ANDA | 2023-06-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| diabetic nephropathies | EFO_0000401 | D003928 | — |
| heart failure | EFO_0003144 | D006333 | I50 |
| hypertension | EFO_0000537 | D006973 | I10 |
| left ventricular dysfunction | — | D018487 | — |
| left ventricular hypertrophy | EFO_0003896 | D017379 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09C: Angiotensin ii receptor blockers (arbs), plain
— C09CA: Angiotensin ii receptor blockers (arbs), plain
— C09CA01: Losartan
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DA: Angiotensin ii receptor blockers (arbs) and diuretics
— C09DA01: Losartan and diuretics
— C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
— C09DB06: Losartan and amlodipine
HCPCS
No data
Clinical
Clinical Trials
342 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 13 | 17 | 39 | 44 | 11 | 119 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | 4 | 4 | 4 | 14 |
| Essential hypertension | D000075222 | I10 | 1 | 3 | 6 | 4 | — | 14 | |
| Diabetic nephropathies | D003928 | EFO_0000401 | 1 | 2 | 3 | 3 | 5 | 13 | |
| Covid-19 | D000086382 | U07.1 | 1 | 6 | 4 | 1 | — | 10 | |
| Proteinuria | D011507 | HP_0000093 | R80 | — | 1 | 3 | 3 | 3 | 10 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | — | 1 | 2 | 2 | 6 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 1 | 4 | 1 | 6 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 2 | 1 | 2 | — | 6 |
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | 1 | 2 | 2 | 5 |
Show 45 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | N18 | — | 1 | 1 | — | 7 | 9 | |
| Marfan syndrome | D008382 | Orphanet_558 | Q87.4 | — | 2 | 6 | — | — | 8 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 3 | 1 | — | — | 4 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | 1 | 1 | 1 | — | — | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | 2 | |
| Cognitive dysfunction | D060825 | G31.84 | — | 2 | 1 | — | — | 2 | |
| Lung neoplasms | D008175 | C34.90 | — | — | 1 | — | 1 | 2 | |
| Pulmonary fibrosis | D011658 | J84.10 | 1 | 2 | 1 | — | — | 2 | |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | 1 | — | 1 | 2 |
| Dyslipidemias | D050171 | HP_0003119 | — | — | 1 | — | — | 1 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 4 | — | — | — | 7 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 3 | — | — | — | 4 |
| Neoplasms | D009369 | C80 | 1 | 2 | — | — | — | 3 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | — | 3 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | 2 | — | — | 1 | 3 |
| Pancreatic ductal carcinoma | D021441 | 1 | 1 | — | — | — | 2 | ||
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 2 | — | — | — | 2 |
| Fibrosis | D005355 | 1 | 2 | — | — | — | 2 | ||
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | 1 | — | — | — | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | 2 | — | — | — | 2 |
Show 28 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 18 | — | — | — | 6 | 24 | ||
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 1 | — | — | — | — | 1 |
| Osteosarcoma | D012516 | 1 | — | — | — | — | 1 | ||
| Myelodysplastic syndromes | D009190 | D46 | 1 | — | — | — | — | 1 | |
| Myeloid leukemia acute | D015470 | C92.0 | 1 | — | — | — | — | 1 | |
| Hematologic neoplasms | D019337 | 1 | — | — | — | — | 1 | ||
| Prostatic neoplasms | D011471 | C61 | 1 | — | — | — | — | 1 | |
| Castration-resistant prostatic neoplasms | D064129 | 1 | — | — | — | — | 1 | ||
| Non-hodgkin lymphoma | D008228 | C85.9 | 1 | — | — | — | — | 1 | |
| Primary myelofibrosis | D055728 | D47.4 | 1 | — | — | — | — | 1 |
Show 19 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 2 | 2 |
| Memory | D008568 | — | — | — | — | 1 | 1 | ||
| Learning | D007858 | — | — | — | — | 1 | 1 | ||
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | 1 | 1 | |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | 1 | 1 | |
| Albuminuria | D000419 | EFO_0004285 | R80.9 | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 1 | 1 |
| Duchenne muscular dystrophy | D020388 | — | — | — | — | 1 | 1 | ||
| Membranous glomerulonephritis | D015433 | EFO_0004254 | N03.2 | — | — | — | — | 1 | 1 |
Show 11 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LOSARTAN |
| INN | losartan |
| Description | Losartan is a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an endothelin receptor antagonist and an anti-arrhythmia drug. It is a biphenylyltetrazole and a member of imidazoles. It is a conjugate acid of a losartan(1-). |
| Classification | Small molecule |
| Drug class | angiotensin II receptor antagonists |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 |
Target
Agency Approved
AGTR1
AGTR1
Organism
Homo sapiens
Gene name
AGTR1
Gene synonyms
AGTR1A, AGTR1B, AT2R1, AT2R1B
NCBI Gene ID
Protein name
type-1 angiotensin II receptor
Protein synonyms
Angiotensin II type-1 receptor, AT1 receptor, AT1AR, AT1BR, type-1B angiotensin II receptor
Uniprot ID
Mouse ortholog
Agtr1b (11608)
type-1 angiotensin II receptor B (P29755)
Alternate
CYP2C9
CYP2C9
Organism
Homo sapiens
Gene name
CYP2C9
Gene synonyms
CYP2C10
NCBI Gene ID
Protein name
cytochrome P450 2C9
Protein synonyms
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, Cholesterol 25-hydroxylase, CYPIIC9, cytochrome P-450 S-mephenytoin 4-hydroxylase, Cytochrome P-450MP, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, cytochrome P450, family 2, subfamily C, polypeptide 9, flavoprotein-linked monooxygenase, microsomal monooxygenase, S-mephenytoin 4-hydroxylase, xenobiotic monooxygenase
Uniprot ID
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Cozaar, Hyzaar, Losartan potassium
Adverse Events
Top Adverse Reactions
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1,608 adverse events reported
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