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Loxitane im, Adasuve(loxapine)
Adasuve, Loxitane (loxapine) is a small molecule pharmaceutical. Loxapine was first approved as Loxitane im on 1982-01-01. It is used to treat psychotic disorders and schizophrenia in the USA. It has been approved in Europe to treat bipolar disorder and schizophrenia. The pharmaceutical is active against 5-hydroxytryptamine receptor 2C, D(4) dopamine receptor, D(2) dopamine receptor, D(3) dopamine receptor, and 5-hydroxytryptamine receptor 2A. In addition, it is known to target 5-hydroxytryptamine receptor 6, histamine H1 receptor, potassium channel subfamily T member 1, and 5-hydroxytryptamine receptor 7.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Adasuve (generic drugs available since 1988-06-15, discontinued: Loxitane, Loxitane c, Loxitane im)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Loxapine
Tradename
Company
Number
Date
Products
ADASUVEAlexza PharmaceuticalsN-022549 RX2012-12-21
1 products, RLD, RS
Loxapine hydrochloride
Tradename
Company
Number
Date
Products
LOXITANE IMAllerganN-018039 DISCN1982-01-01
1 products
LOXITANE CTevaN-017658 DISCN1982-01-01
1 products
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Loxapine succinate
Tradename
Company
Number
Date
Products
LOXITANETevaN-017525 DISCN1982-01-01
7 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
adasuveNew Drug Application2022-03-07
loxapineANDA2023-03-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
psychotic disorders—D011618F20.81
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Loxapine, Adasuve, Alexza Pharms
83876122026-10-23DP
75370092024-10-28DP
74583742024-08-18DP
89913872024-05-21DP
93706292024-05-20DP
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AH: Diazepines, oxazepines, thiazepines and oxepines antipsychotic drugs
— N05AH01: Loxapine
HCPCS
Code
Description
J2062
Loxapine for inhalation, 1 mg
Clinical
Clinical Trials
27 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Psychomotor agitationD011595——1236
Healthy volunteers/patients—2——2—4
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20111—14
Bipolar disorderD001714EFO_0000289F30.9——2——2
Emergence deliriumD000071257——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43—2———2
NeuralgiaD009437EFO_0009430—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AsthmaD001249EFO_0000270J451————1
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.91————1
Cigarette smokingD0000738651————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory insufficiencyD012131HP_0002093J96.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLOXAPINE
INNloxapine
Description
Loxapine is a dibenzooxazepine. It has a role as an antipsychotic agent and a dopaminergic antagonist.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1
Identifiers
PDB—
CAS-ID1977-10-2
RxCUI6475
ChEMBL IDCHEMBL831
ChEBI ID50841
PubChem CID3964
DrugBankDB00408
UNII IDLER583670J (ChemIDplus, GSRS)
Target
Agency Approved
HTR2C
HTR2C
DRD4
DRD4
DRD2
DRD2
DRD3
DRD3
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR2C
Gene synonyms
HTR1C
NCBI Gene ID
3358
Protein name
5-hydroxytryptamine receptor 2C
Protein synonyms
5-HT-1C, 5-HT1C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 5-HT-1C receptor, serotonin 5-HT-2C receptor, Serotonin receptor 2C
Uniprot ID
Q9NP28
Mouse ortholog
Htr2c (15560)
5-hydroxytryptamine receptor 2C (Q5WRU6)
Alternate
HTR6
HTR6
HRH1
HRH1
KCNT1
KCNT1
HTR7
HTR7
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
3362
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Q5TGZ1
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,132 documents
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Safety
Black-box Warning
Black-box warning for: Adasuve, Loxapine
Adverse Events
Top Adverse Reactions
Mock data
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3,647 adverse events reported
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