Lutropin alfa
Luveris, Pergoveris (lutropin alfa) is a protein pharmaceutical. Lutropin alfa was first approved as Luveris on 2000-11-29. It is used to treat female infertility in the USA. It has been approved in Europe to treat female infertility and ovulation induction. The pharmaceutical is active against lutropin-choriogonadotropic hormone receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| therapeutics | D013812 |
| investigative techniques | D008919 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| female infertility | EFO_0008560 | D007247 | N97 |
Agency Specific
FDA
EMA
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Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
56 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Prostatectomy | D011468 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 | ||
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | 1 | 1 | |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | — | — | — | — | 1 | 1 |
| Galactosemias | D005693 | E74.21 | — | — | — | — | 1 | 1 | |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
| Porphyrias | D011164 | EFO_0000665 | E80.20 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LUTROPIN ALFA |
| INN | lutropin alfa |
| Description | Lutropin beta chain precursor (Luteinizing hormone beta subunit) (LSH-beta) |
| Classification | Protein |
| Drug class | tricyclic compounds; atropine derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201419 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3JGY52XJNA (ChemIDplus, GSRS) |
Target
Agency Approved
LHCGR
LHCGR
Organism
Homo sapiens
Gene name
LHCGR
Gene synonyms
LCGR, LGR2, LHRHR
NCBI Gene ID
Protein name
lutropin-choriogonadotropic hormone receptor
Protein synonyms
hypergonadotropic hypogonadism, LHR, LSH-R, Luteinizing hormone receptor, lutropin/choriogonadotropin receptor
Uniprot ID
Mouse ortholog
Lhcgr (16867)
lutropin-choriogonadotropic hormone receptor (P30730)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 326 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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43 adverse events reported
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