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Mapatumumab
Mapatumumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target tumor necrosis factor ligand superfamily member 10.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289—2———2
Liver neoplasmsD008113EFO_1001513C22.021———2
Multiple myelomaD009101C90.0—1———1
Uterine cervical neoplasmsD00258311———1
Non-hodgkin lymphomaD008228C85.9—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMAPATUMUMAB
INNmapatumumab
Description
Mapatumumab (human mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID658052-09-6
RxCUI—
ChEMBL IDCHEMBL2108621
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDWZ1025JPGR (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TNFSF10
TNFSF10
Organism
Homo sapiens
Gene name
TNFSF10
Gene synonyms
APO2L, TRAIL
NCBI Gene ID
8743
Protein name
tumor necrosis factor ligand superfamily member 10
Protein synonyms
Apo-2 ligand, Apo-2L, CD253, chemokine tumor necrosis factor ligand superfamily member 10, Protein TRAIL, TNF-related apoptosis inducing ligand TRAIL, TNF-related apoptosis-inducing ligand, tumor necrosis factor (ligand) family, member 10, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor ligand 6A, tumor necrosis factor superfamily member 10
Uniprot ID
P50591
Mouse ortholog
Tnfsf10 (22035)
tumor necrosis factor ligand superfamily member 10 (P50592)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 436 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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