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Marimastat
Marimastat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target matrix metalloproteinase-9, interstitial collagenase, matrilysin, stromelysin-1, and 72 kDa type IV collagenase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lung neoplasmsD008175C34.90——2——2
Breast neoplasmsD001943EFO_0003869C50——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMARIMASTAT
INNmarimastat
Description
Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid.
Classification
Small molecule
Drug classenzyme inhibitors: matrix metalloprotease inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Identifiers
PDB—
CAS-ID154039-60-8
RxCUI—
ChEMBL IDCHEMBL279785
ChEBI ID50662
PubChem CID119031
DrugBankDB00786
UNII IDD5EQV23TDS (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MMP9
MMP9
MMP1
MMP1
MMP7
MMP7
MMP3
MMP3
MMP2
MMP2
Organism
Homo sapiens
Gene name
MMP9
Gene synonyms
CLG4B
NCBI Gene ID
4318
Protein name
matrix metalloproteinase-9
Protein synonyms
92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB, macrophage gelatinase, matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), type V collagenase
Uniprot ID
Q9UDK2
Mouse ortholog
Mmp9 (17395)
matrix metalloproteinase-9 (Q9DC02)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,433 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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